RHOC

RHOC
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Z2C, 2GCN, 2GCO, 2GCP
Dynodwyr
Cyfenwau	RHOC, ARH9, ARHC, H9, RHOH9, RhoC, ras homolog family member C
Dynodwyr allanol	OMIM: 165380 HomoloGene: 90945 GeneCards: RHOC
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • signal transducer activity; • GO:0006184 GTPase activity;
Cydrannau o'r gell	• cytosol; • Cellbilen; • cleavage furrow; • extracellular exosome; • bilen; • cnewyllyn cell; • intracellular anatomical structure; • stereocilium;
Prosesau biolegol	• positive regulation of I-kappaB kinase/NF-kappaB signaling; • skeletal muscle satellite cell migration; • regulation of small GTPase mediated signal transduction; • apical junction assembly; • wound healing, spreading of cells; • positive regulation of lipase activity; • small GTPase mediated signal transduction; • positive regulation of protein homooligomerization; • mitotic cytokinesis; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	389
	n/a
	ENSG00000155366
	n/a
	P08134; Q5JR06
	n/a
	NM_175744; NM_001042678; NM_001042679
	n/a
	NP_001036143; NP_001036144; NP_786886
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHOC yw RHOC a elwir hefyd yn Rho-related GTP-binding protein RhoC a Ras homolog family member C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHOC.

H9
ARH9
ARHC
RHOH9

Llyfryddiaeth

"Effects and mechanism of RhoC downregulation in suppressing ovarian cancer stem cell proliferation, drug resistance, invasion and metastasis. ". Oncol Rep. 2016. PMID 27748937.
"RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. ". J Biol Chem. 2016. PMID 27129239.
"Smart Nanoparticles Enhance the Cytoplasmic Delivery of Anti-RhoC Silencing RNA and Inhibit the Migration and Invasion of Aggressive Breast Cancer Cells. ". Mol Pharm. 2015. PMID 26020100.
"RhoC mediates epidermal growth factor-stimulated migration and invasion in head and neck squamous cell carcinoma. ". Neoplasia. 2015. PMID 25622907.
"RhoC upregulation is correlated with reduced E-cadherin in human breast cancer specimens after chemotherapy and in human breast cancer MCF-7 cells.". Horm Cancer. 2014. PMID 25123151.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RHOC - Cronfa NCBI

[1]

[2]