RMI1

RMI1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3MXN, 3NBH, 3NBI, 4CGY, 4CHT, 4DAY
Dynodwyr
Cyfenwau	RMI1, BLAP75, C9orf76, FAAP75, RecQ mediated genome instability 1
Dynodwyr allanol	OMIM: 610404 HomoloGene: 41601 GeneCards: RMI1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cnewyllyn cell; • nucleoplasm; • nuclear body; • RecQ family helicase-topoisomerase III complex;
Prosesau biolegol	• DNA replication; • response to dietary excess; • reduction of food intake in response to dietary excess; • response to glucose; • multicellular organism growth; • glucose homeostasis; • resolution of meiotic recombination intermediates; • double-strand break repair via homologous recombination; • regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologau
	80010
	n/a
	ENSG00000178966
	n/a
	Q9H9A7
	n/a
	NM_024945; NM_001358291; NM_001358292; NM_001358293; NM_001358294
	n/a
	NP_079221; NP_001345220; NP_001345221; NP_001345222; NP_001345223
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RMI1 yw RMI1 a elwir hefyd yn RecQ mediated genome instability 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RMI1.

BLAP75
FAAP75
C9orf76

Llyfryddiaeth

"RMI1 promotes DNA replication fork progression and recovery from replication fork stress. ". Mol Cell Biol. 2012. PMID 22645306.
"Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma. ". Cancer Lett. 2007. PMID 17900800.
"Knockdown of RMI1 impairs DNA repair under DNA replication stress. ". Biochem Biophys Res Commun. 2017. PMID 29042194.
"Structural Motifs Critical for In Vivo Function and Stability of the RecQ-Mediated Genome Instability Protein Rmi1. ". PLoS One. 2015. PMID 26717309.
"Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.". Int J Mol Sci. 2015. PMID 26556339.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RMI1 - Cronfa NCBI

[1]

[2]