RND1

RND1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CLS, 2REX, 3Q3J
Dynodwyr
Cyfenwau	RND1, ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1
Dynodwyr allanol	OMIM: 609038 HomoloGene: 8706 GeneCards: RND1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GTP binding; • signaling receptor binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • adherens junction; • cytosol; • Cytosgerbwd; • bilen; • Cellbilen; • actin cytoskeleton; • intracellular membrane-bounded organelle; • intracellular anatomical structure; • cell cortex; • cell division site;
Prosesau biolegol	• neuron remodeling; • small GTPase mediated signal transduction; • negative regulation of cell adhesion; • actin filament organization; • Rho protein signal transduction; • regulation of cell shape; • regulation of cell migration; • establishment or maintenance of actin cytoskeleton polarity; • regulation of actin cytoskeleton organization; • actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologau
	27289
	n/a
	ENSG00000172602
	n/a
	Q92730
	n/a
	NM_014470
	n/a
	NP_055285
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RND1 yw RND1 a elwir hefyd yn Rho-related GTP-binding protein Rho6 a Rho family GTPase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RND1.

ARHS
RHO6
RHOS

Llyfryddiaeth

"Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs). ". J Biol Chem. 2011. PMID 21610070.
"Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. ". Biochem Biophys Res Commun. 2000. PMID 11095956.
"RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells. ". Tumour Biol. 2016. PMID 26250459.
"The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. ". Nat Cell Biol. 2015. PMID 25531777.
"Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.". Biochem Soc Trans. 2016. PMID 27913679.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RND1 - Cronfa NCBI

[1]

[2]