RNF8

RNF8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CSW, 2PIE, 4AYC, 4ORH, 4WHV
Dynodwyr
Cyfenwau	RNF8, hring finger protein 8
Dynodwyr allanol	OMIM: 611685 HomoloGene: 2944 GeneCards: RNF8
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • GO:0031493 histone binding; • chromatin binding; • metal ion binding; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948, GO:0016582 protein binding; • ubiquitin protein ligase binding; • transferase activity; • identical protein binding; • zinc ion binding; • ubiquitin binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity;
Cydrannau o'r gell	• site of double-strand break; • ubiquitin ligase complex; • nucleoplasm; • Cromosom; • telomere; • midbody; • cnewyllyn cell; • cytosol; • cytoplasm;
Prosesau biolegol	• response to ionizing radiation; • histone H2A ubiquitination; • interstrand cross-link repair; • ubiquitin-dependent protein catabolic process; • protein K63-linked ubiquitination; • GO:1900404 positive regulation of DNA repair; • histone H2A K63-linked ubiquitination; • negative regulation of transcription elongation from RNA polymerase II promoter; • cellular response to DNA damage stimulus; • Cellraniad; • protein K48-linked ubiquitination; • isotype switching; • protein ubiquitination; • spermatid development; • cell cycle; • histone H2B ubiquitination; • double-strand break repair via nonhomologous end joining; • GO:0035042 histone exchange; • protein autoubiquitination; • double-strand break repair; • GO:0100026 DNA repair; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Sources:Amigo / QuickGO
Orthologau
	9025
	n/a
	ENSG00000112130
	n/a
	O76064
	n/a
	NM_003958; NM_183078
	n/a
	NP_003949; NP_898901
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF8 yw RNF8 a elwir hefyd yn Ring finger protein 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNF8.

hRNF8

Llyfryddiaeth

"Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. ". Oncotarget. 2016. PMID 26788910.
"RNF8 plays an important role in the radioresistance of human nasopharyngeal cancer cells in vitro. ". Oncol Rep. 2015. PMID 25955491.
"RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. ". J Exp Med. 2017. PMID 28507061.
"RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling. ". Biochem Biophys Res Commun. 2017. PMID 28499869.
"RNF8 promotes epithelial-mesenchymal transition of breast cancer cells.". J Exp Clin Cancer Res. 2016. PMID 27259701.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RNF8 - Cronfa NCBI

[1]

[2]