RORA

RORA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1N83, 1S0X, 4S15
Dynodwyr
Cyfenwau	RORA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, RAR related orphan receptor A, IDDECA
Dynodwyr allanol	OMIM: 600825 HomoloGene: 56594 GeneCards: RORA
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • beta-catenin binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • ligand-activated transcription factor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • transcription factor binding; • metal ion binding; • steroid hormone receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • core promoter sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • transcription coactivator binding; • transcription corepressor binding; • oxysterol binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell;
Prosesau biolegol	• negative regulation of fat cell differentiation; • nitric oxide biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • cGMP metabolic process; • proses rythmig; • cellular response to sterol; • cellular response to tumor necrosis factor; • cerebellar Purkinje cell differentiation; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • circadian regulation of gene expression; • transcription, DNA-templated; • cerebellar granule cell precursor proliferation; • regulation of steroid metabolic process; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of smoothened signaling pathway; • muscle cell differentiation; • intracellular receptor signaling pathway; • regulation of glucose metabolic process; • regulation of circadian rhythm; • angiogenesis; • cellular response to interleukin-1; • xenobiotic metabolic process; • positive regulation of circadian rhythm; • positive regulation of vascular endothelial growth factor production; • T-helper 17 cell differentiation; • transcription initiation from RNA polymerase II promoter; • negative regulation of inflammatory response; • cellular response to hypoxia; • triglyceride homeostasis; • regulation of macrophage activation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • steroid hormone mediated signaling pathway; • Rhythm circadaidd; • cytokine-mediated signaling pathway; • cholesterol homeostasis; • multicellular organism development;
	Sources:Amigo / QuickGO
Orthologau
	6095
	n/a
	ENSG00000069667
	n/a
	P35398
	n/a
	NM_002943; NM_134260; NM_134261; NM_134262
	n/a
	NP_002934; NP_599022; NP_599023; NP_599024
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RORA yw RORA a elwir hefyd yn RAR related orphan receptor A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RORA.

ROR1
ROR2
ROR3
RZRA
NR1F1
RZR-ALPHA

Llyfryddiaeth

"Support for the association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China. ". Asian J Psychiatr. 2017. PMID 28262136.
"Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. ". Exp Cell Res. 2017. PMID 28238834.
"RAR-related orphan receptor A (RORA): A new susceptibility gene for multiple sclerosis. ". J Neurol Sci. 2016. PMID 27653902.
"Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. ". EBioMedicine. 2016. PMID 27568222.
"Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats.". Epilepsy Behav. 2016. PMID 26731717.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RORA - Cronfa NCBI

[1]

[2]