RPS3

RPS3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WH9, 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC
Dynodwyr
Cyfenwau	RPS3, S3, ribosomal protein S3
Dynodwyr allanol	OMIM: 600454 HomoloGene: 779 GeneCards: RPS3
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• tubulin binding; • DNA N-glycosylase activity; • small ribosomal subunit rRNA binding; • iron-sulfur cluster binding; • transcription factor binding; • oxidized purine DNA binding; • Hsp70 protein binding; • lyase activity; • enzyme binding; • mRNA binding; • structural constituent of ribosome; • damaged DNA binding; • ubiquitin-like protein conjugating enzyme binding; • GO:0001948, GO:0016582 protein binding; • DNA-(apurinic or apyrimidinic site) endonuclease activity; • oxidized pyrimidine DNA binding; • endodeoxyribonuclease activity; • protein kinase binding; • supercoiled DNA binding; • DNA binding; • Hsp90 protein binding; • microtubule binding; • protein kinase A binding; • RNA binding; • kinase binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0032403 protein-containing complex binding; • class I DNA-(apurinic or apyrimidinic site) endonuclease activity; • class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity; • oxidized purine nucleobase lesion DNA N-glycosylase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • polysome; • bilen; • focal adhesion; • ruffle membrane; • mitocondria; • Cytosgerbwd; • cnewyllyn cell; • ribosom; • nucleolus; • extracellular exosome; • Cellbilen; • spindle; • mitochondrial matrix; • small ribosomal subunit; • mitotic spindle; • mitochondrial inner membrane; • cytosolic small ribosomal subunit; • nucleoplasm; • GO:0005578 extracellular matrix; • Reticwlwm endoplasmig; • NF-kappaB complex; • GO:0097483, GO:0097481 postsynaptic density; • ribonucleoprotein complex; • synapse;
Prosesau biolegol	• chromosome segregation; • positive regulation of endodeoxyribonuclease activity; • cellular response to DNA damage stimulus; • positive regulation of microtubule polymerization; • cell cycle; • GO:0097285 apoptotic process; • negative regulation of translation; • GO:0009373 regulation of transcription, DNA-templated; • viral transcription; • response to TNF agonist; • positive regulation of apoptotic signaling pathway; • GO:0001306 response to oxidative stress; • transcription, DNA-templated; • SRP-dependent cotranslational protein targeting to membrane; • positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; • positive regulation of DNA N-glycosylase activity; • positive regulation of JUN kinase activity; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • negative regulation of DNA repair; • GO:1900404 positive regulation of DNA repair; • positive regulation of NIK/NF-kappaB signaling; • Cellraniad; • spindle assembly; • negative regulation of protein ubiquitination; • GO:1901313 positive regulation of gene expression; • translational initiation; • regulation of translation; • cellular response to hydrogen peroxide; • protein biosynthesis; • positive regulation of base-excision repair; • GO:0100026 DNA repair; • regulation of apoptotic process; • rRNA processing; • cytoplasmic translation; • positive regulation of protein-containing complex assembly; • positive regulation of interleukin-2 production; • positive regulation of activated T cell proliferation; • positive regulation of T cell receptor signaling pathway; • positive regulation of NF-kappaB transcription factor activity; • cellular response to tumor necrosis factor;
	Sources:Amigo / QuickGO
Orthologau
	6188
	n/a
	ENSG00000149273
	n/a
	P23396
	n/a
	NM_001260507; NM_001005; NM_001256802; NM_001260506
	n/a
	NP_000996; NP_001243731; NP_001247435; NP_001247436
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RPS3 yw RPS3 a elwir hefyd yn Ribosomal protein S3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.4.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RPS3.

S3

Llyfryddiaeth

"Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. ". Toxicology. 2010. PMID 20709134.
"[Protein S3 fragments neighboring mRNA during elongation and translation termination on the human ribosome]. ". Bioorg Khim. 2008. PMID 19088750.
"Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit. ". Nucleic Acids Res. 2017. PMID 28334742.
"Eukaryotic ribosomal protein S3: A constituent of translational machinery and an extraribosomal player in various cellular processes. ". Biochimie. 2014. PMID 24239944.
"Ribosomal protein S3 is secreted as a homodimer in cancer cells.". Biochem Biophys Res Commun. 2013. PMID 24211576.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RPS3 - Cronfa NCBI

[1]

[2]