RPS6KA5

RPS6KA5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1VZO, 3KN5, 3KN6
Dynodwyr
Cyfenwau	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
Dynodwyr allanol	OMIM: 603607 HomoloGene: 48302 GeneCards: RPS6KA5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • magnesium ion binding • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell Prosesau biolegol • GO:0007243 intracellular signal transduction • GO:0009373 regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • phosphorylation • stimulatory C-type lectin receptor signaling pathway • axon guidance • positive regulation of histone acetylation • interleukin-1-mediated signaling pathway • protein phosphorylation • positive regulation of CREB transcription factor activity • positive regulation of NF-kappaB transcription factor activity • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • GO:0032697 negative regulation of cytokine production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9252	n/a
Ensembl	ENSG00000100784	n/a
UniProt	O75582	n/a
RefSeq (mRNA)	NM_004755 NM_182398 NM_001322227 NM_001322228 NM_001322229 NM_001322230 NM_001322231 NM_001322232 NM_001322233 NM_001322234 NM_001322235 NM_001322236 NM_001322237 NM_001322238	n/a
RefSeq (protein)	NP_001309156 NP_001309157 NP_001309158 NP_001309159 NP_001309160 NP_001309161 NP_001309162 NP_001309163 NP_001309164 NP_001309165 NP_001309166 NP_001309167 NP_004746 NP_872198	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RPS6KA5 yw RPS6KA5 a elwir hefyd yn Ribosomal protein S6 kinase A5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q32.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RPS6KA5.

• MSK1
• RLPK
• MSPK1

Llyfryddiaeth

• "Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. ". Biochem J. 2007. PMID 17117922.
• "Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokines. ". J Invest Dermatol. 2006. PMID 16543895.
• "Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes. ". BMC Cancer. 2015. PMID 25958199.
• "Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins. ". Oncogene. 2014. PMID 23604116.
• "Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing.". Proc Natl Acad Sci U S A. 2011. PMID 21282660.

Cyfeiriadau

1. "Human PubMed Reference:".
2. RPS6KA5 - Cronfa NCBI