RRM2B

RRM2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2VUX, 3HF1, 4DJN
Dynodwyr
Cyfenwau	RRM2B, MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B, RCDFRD
Dynodwyr allanol	OMIM: 604712 HomoloGene: 56723 GeneCards: RRM2B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • GO:0001948, GO:0016582 protein binding; • oxidoreductase activity; • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;
Cydrannau o'r gell	• mitocondria; • cnewyllyn cell; • nucleoplasm; • cytoplasm; • cytosol; • ribonucleoside-diphosphate reductase complex;
Prosesau biolegol	• deoxyribonucleoside triphosphate metabolic process; • renal system process; • kidney development; • GO:0001306 response to oxidative stress; • mitochondrial DNA replication; • cellular response to DNA damage stimulus; • deoxyribonucleotide biosynthetic process; • DNA replication; • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • response to amine; • GO:0100026 DNA repair; • nucleobase-containing small molecule interconversion;
	Sources:Amigo / QuickGO
Orthologau
	50484
	n/a
	ENSG00000048392
	n/a
	Q7LG56
	n/a
	NM_015713; NM_001172477; NM_001172478
	n/a
	NP_001165948; NP_001165949; NP_056528
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RRM2B yw RRM2B a elwir hefyd yn Ribonucleotide reductase regulatory TP53 inducible subunit M2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RRM2B.

P53R2
MTDPS8A
MTDPS8B

Llyfryddiaeth

"Synergism between clofarabine and decitabine through p53R2: a pharmacodynamic drug-drug interaction modeling. ". Leuk Res. 2012. PMID 22884950.
"Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells. ". Proc Natl Acad Sci U S A. 2012. PMID 22847445.
RRM2B-Related Mitochondrial Disease. 1993. PMID 24741716.
"Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. ". Hepatology. 2014. PMID 24214128.
"p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells.". J Dermatol Sci. 2012. PMID 22902076.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RRM2B - Cronfa NCBI

[1]

[2]