S1PR1

S1PR1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3V2W, 3V2Y
Dynodwyr
Cyfenwau	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
Dynodwyr allanol	OMIM: 601974 HomoloGene: 1071 GeneCards: S1PR1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sphingolipid binding; • sphingosine-1-phosphate receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled receptor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • endosome; • bilen; • intrinsic component of plasma membrane; • Cellbilen; • membrane raft; • external side of plasma membrane; • nucleoplasm; • intracellular membrane-bounded organelle;
Prosesau biolegol	• actin cytoskeleton reorganization; • T cell migration; • G protein-coupled receptor signaling pathway; • heart trabecula morphogenesis; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • sphingosine-1-phosphate receptor signaling pathway; • positive regulation of cell migration; • regulation of bone mineralization; • transmission of nerve impulse; • chemotaxis; • positive regulation of positive chemotaxis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • brain development; • regulation of cell adhesion; • cell adhesion; • angiogenesis; • neuron differentiation; • positive regulation of cell population proliferation; • endothelial cell differentiation; • negative regulation of stress fiber assembly; • regulation of bone resorption; • cell migration; • GO:0072468 signal transduction; • lamellipodium assembly; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cardiac muscle tissue growth involved in heart morphogenesis; • positive regulation of smooth muscle cell proliferation; • blood vessel maturation; • leukocyte chemotaxis; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	1901
	n/a
	ENSG00000170989
	n/a
	P21453
	n/a
	NM_001400; NM_001320730
	n/a
	NP_001307659; NP_001391
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn S1PR1 yw S1PR1 a elwir hefyd yn Sphingosine-1-phosphate receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn S1PR1.

EDG1
S1P1
CD363
ECGF1
EDG-1
CHEDG1
D1S3362

Llyfryddiaeth

"Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. ". Exp Mol Pathol. 2017. PMID 28986246.
"Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. ". Invest Ophthalmol Vis Sci. 2017. PMID 28492873.
"Activation mechanisms of the first sphingosine-1-phosphate receptor. ". Protein Sci. 2017. PMID 28370663.
"Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. ". J R Soc Interface. 2016. PMID 27974574.
"The effect of S1P receptor signaling pathway on the survival and drug resistance in multiple myeloma cells.". Mol Cell Biochem. 2017. PMID 27785703.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] S1PR1 - Cronfa NCBI

[1]

[2]