SAP18

SAP18
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2HDE
Dynodwyr
Cyfenwau	SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
Dynodwyr allanol	OMIM: 602949 HomoloGene: 4289 GeneCards: SAP18
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001106 transcription corepressor activity; • GO:0001948, GO:0016582 protein binding; • histone deacetylase activity; • RNA binding;
Cydrannau o'r gell	• histone deacetylase complex; • nuclear speck; • exon-exon junction complex; • nucleoplasm; • ASAP complex; • cnewyllyn cell; • cytoplasm; • cytosol; • nuclear body;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • mRNA processing; • regulation of alternative mRNA splicing, via spliceosome; • transcription, DNA-templated; • negative regulation of mRNA splicing, via spliceosome; • RNA splicing; • positive regulation of apoptotic process; • negative regulation of nucleic acid-templated transcription; • histone deacetylation;
	Sources:Amigo / QuickGO
Orthologau
	10284
	n/a
	ENSG00000150459
	n/a
	O00422
	n/a
	NM_005870; NM_001366643
	n/a
	NP_005861; NP_001353572
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SAP18 yw SAP18 a elwir hefyd yn Histone deacetylase complex subunit SAP18 a Sin3A associated protein 18 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q12.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SAP18.

SAP18P
2HOR0202

Llyfryddiaeth

"Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. ". J Biol Chem. 2006. PMID 16537548.
"INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. ". Retrovirology. 2013. PMID 23799881.
"Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. ". Biochemistry. 2006. PMID 17002296.
"An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability. ". J Virol. 2016. PMID 27558426.
"Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.". J Lipid Res. 2015. PMID 25921304.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SAP18 - Cronfa NCBI

[1]

[2]