SELP

SELP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FSB, 1G1Q, 1G1R, 1G1S, 1HES
Dynodwyr
Cyfenwau	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, selectin P
Dynodwyr allanol	OMIM: 173610 HomoloGene: 2260 GeneCards: SELP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • oligosaccharide binding; • lipopolysaccharide binding; • calcium-dependent protein binding; • glycosphingolipid binding; • fucose binding; • carbohydrate binding; • sialic acid binding; • GO:0001948, GO:0016582 protein binding; • calcium ion binding; • metal ion binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • platelet alpha granule membrane; • platelet dense granule membrane; • external side of plasma membrane; • extracellular space; • integral component of plasma membrane; • Cellbilen;
Prosesau biolegol	• leukocyte cell-cell adhesion; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • positive regulation of leukocyte migration; • platelet degranulation; • regulation of integrin activation; • cell adhesion; • GO:0051636 defense response to Gram-negative bacterium; • positive regulation of phosphatidylinositol 3-kinase signaling; • inflammatory response; • calcium-mediated signaling using intracellular calcium source; • positive regulation of platelet activation; • leukocyte migration; • response to lipopolysaccharide; • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; • leukocyte tethering or rolling;
	Sources:Amigo / QuickGO
Orthologau
	6403
	n/a
	ENSG00000174175
	n/a
	P16109
	n/a
	NM_003005
	n/a
	NP_002996; NP_002996.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SELP yw SELP a elwir hefyd yn Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_b a Selectin P (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q24.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SELP.

CD62
GRMP
PSEL
CD62P
GMP140
LECAM3
PADGEM

Llyfryddiaeth[golygu | golygu cod]

"Mechanical regulation of calcium signaling of HL-60 on P-selectin under flow. ". Biomed Eng Online. 2016. PMID 28155729.
"Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow. ". Protein Cell. 2017. PMID 28097631.
"Enhanced P-selectin expression on platelet-a marker of platelet activation, in young patients with angiographically proven coronary artery disease. ". Mol Cell Biochem. 2016. PMID 27406211.
"Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy. ". Int J Biol Macromol. 2016. PMID 27234491.
"The Synergistic Effect of Serine with Selenocompounds on the Expression of SelP and GPx in HepG2 Cells.". Biol Trace Elem Res. 2016. PMID 26944060.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] SELP - Cronfa NCBI

[1]

[2]