SERPINA1

SERPINA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ATU, 1D5S, 1EZX, 1HP7, 1IZ2, 1KCT, 1OO8, 1OPH, 1PSI, 1QLP, 1QMB, 2D26, 2QUG, 3CWL, 3CWM, 3DRM, 3DRU, 3NDD, 3NDF, 3NE4, 3T1P, 7API, 8API, 9API, 4PYW, 5IO1
Dynodwyr
Cyfenwau	SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, serpin family A member 1, nNIF
Dynodwyr allanol	OMIM: 107400 HomoloGene: 20103 GeneCards: SERPINA1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• peptidase inhibitor activity; • protease binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • serine-type endopeptidase inhibitor activity;
Cydrannau o'r gell	• Golgi apparatus; • endoplasmic reticulum lumen; • COPII-coated ER to Golgi transport vesicle; • extracellular exosome; • endoplasmic reticulum-Golgi intermediate compartment membrane; • platelet alpha granule lumen; • extracellular region; • Reticwlwm endoplasmig; • Golgi membrane; • extracellular space; • intracellular membrane-bounded organelle; • ficolin-1-rich granule lumen; • collagen-containing extracellular matrix;
Prosesau biolegol	• hemostasis; • negative regulation of peptidase activity; • platelet degranulation; • endoplasmic reticulum to Golgi vesicle-mediated transport; • COPII vesicle coating; • acute-phase response; • negative regulation of endopeptidase activity; • blood coagulation; • neutrophil degranulation; • post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologau
	5265
	n/a
	ENSG00000197249; ENSG00000277377
	n/a
	P01009
	n/a
NM_001127707; NM_000295; NM_001002235; NM_001002236; NM_001127700;
	NM_001127701; NM_001127702; NM_001127703; NM_001127704; NM_001127705; NM_001127706
	n/a
NP_000286; NP_001002235; NP_001002236; NP_001121172; NP_001121173;
	NP_001121174; NP_001121175; NP_001121176; NP_001121177; NP_001121178; NP_001121179
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINA1 yw SERPINA1 a elwir hefyd yn Alpha-1-antitrypsin a Serpin family A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q32.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINA1.

PI
A1A
AAT
PI1
A1AT
nNIF
PRO2275
alpha1AT

Llyfryddiaeth

"The prevalence of PI*S and PI*Z SERPINA1 alleles in healthy individuals and COPD patients in Saudi Arabia: A case-control study. ". Medicine (Baltimore). 2017. PMID 29049242.
"Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity. ". PLoS One. 2017. PMID 28922398.
"Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance. ". J Leukoc Biol. 2017. PMID 28716864.
"Alpha-1-antitrypsin for the treatment of steroid-refractory acute gastrointestinal graft-versus-host disease. ". Am J Hematol. 2017. PMID 28699171.
"A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma.". Tumour Biol. 2017. PMID 28618946.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SERPINA1 - Cronfa NCBI

[1]

[2]