SERPINB1

SERPINB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4GA7
Dynodwyr
Cyfenwau	SERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
Dynodwyr allanol	OMIM: 130135 HomoloGene: 133768 GeneCards: SERPINB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• peptidase inhibitor activity; • serine-type endopeptidase inhibitor activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • extracellular exosome; • bilen; • extracellular space; • secretory granule lumen; • GO:0005578 extracellular matrix; • extracellular region; • collagen-containing extracellular matrix;
Prosesau biolegol	• negative regulation of peptidase activity; • negative regulation of endopeptidase activity; • neutrophil degranulation; • type B pancreatic cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	1992
	n/a
	ENSG00000021355
	n/a
	P30740
	n/a
	NM_030666
	n/a
	NP_109591
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINB1 yw SERPINB1 a elwir hefyd yn Serpin family B member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p25.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINB1.

EI
LEI
PI2
MNEI
PI-2
HEL57
M/NEI
ELANH2
HEL-S-27

Llyfryddiaeth

"SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma. ". Oncotarget. 2016. PMID 26799424.
"Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells. ". Brain Res. 2015. PMID 24968089.
"Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients. ". J Immunotoxicol. 2015. PMID 24852194.
"Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. ". J Mol Histol. 2014. PMID 24105272.
"Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.". Am J Physiol Gastrointest Liver Physiol. 2012. PMID 22421620.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SERPINB1 - Cronfa NCBI

[1]

[2]