SERPINB2

SERPINB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ARR, 1BY7, 1JRR, 2ARQ
Dynodwyr
Cyfenwau	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
Dynodwyr allanol	OMIM: 173390 HomoloGene: 20571 GeneCards: SERPINB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• peptidase inhibitor activity; • serine-type endopeptidase inhibitor activity;
Cydrannau o'r gell	• extracellular region; • Cellbilen; • extracellular space; • cytoplasm;
Prosesau biolegol	• negative regulation of peptidase activity; • wound healing; • negative regulation of apoptotic process; • fibrinolysis; • negative regulation of endopeptidase activity; • interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	5055
	n/a
	ENSG00000197632
	n/a
	P05120
	n/a
	NM_002575; NM_001143818
	n/a
	NP_001137290; NP_002566
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINB2 yw SERPINB2 a elwir hefyd yn Plasminogen activator inhibitor 2 a Serpin family B member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q21.33-q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINB2.

PAI
PAI2
PAI-2
PLANH2
HsT1201

Llyfryddiaeth

"SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs. ". Mol Immunol. 2017. PMID 28578223.
"Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation. ". Atherosclerosis. 2016. PMID 27174532.
"Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population. ". Lipids Health Dis. 2015. PMID 26573152.
"The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2. ". Exp Cell Res. 2015. PMID 25704756.
"SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer.". Mol Carcinog. 2014. PMID 23661500.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SERPINB2 - Cronfa NCBI

[1]

[2]