SFN

SFN
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1YWT, 1YZ5, 3IQJ, 3IQU, 3IQV, 3LW1, 3MHR, 3O8I, 3P1N, 3P1O, 3P1P, 3P1Q, 3P1R, 3P1S, 3SMK, 3SML, 3SMM, 3SMN, 3SMO, 3SPR, 3T0L, 3T0M, 3U9X, 3UX0, 4DAT, 4DAU, 4DHM, 4DHN, 4DHO, 4DHP, 4DHQ, 4DHR, 4DHS, 4DHT, 4DHU, 4FL5, 4FR3, 4HQW, 4HRU, 4IEA, 4JC3, 4JDD, 4QLI, 5HF3, 4Y5I, 4Y32, 4Y3B, 3SP5
Dynodwyr
Cyfenwau	SFN, YWHAS, Stratifin
Dynodwyr allanol	OMIM: 601290 HomoloGene: 4475 GeneCards: SFN
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein domain specific binding; • phosphoprotein binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • protein kinase C inhibitor activity; • identical protein binding; • cadherin binding;
Cydrannau o'r gell	• extracellular region; • extracellular exosome; • cytoplasmic vesicle membrane; • cnewyllyn cell; • mitocondria; • extracellular space; • cytoplasm; • cytosol;
Prosesau biolegol	• regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of keratinocyte proliferation; • negative regulation of protein kinase activity; • establishment of skin barrier; • keratinization; • keratinocyte differentiation; • regulation of cell cycle; • positive regulation of protein export from nucleus; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • keratinocyte development; • positive regulation of cell growth; • regulation of epidermal cell division; • intrinsic apoptotic signaling pathway in response to DNA damage; • membrane organization; • positive regulation of epidermal cell differentiation; • GO:0072468 signal transduction; • release of cytochrome c from mitochondria; • skin development; • negative regulation of protein serine/threonine kinase activity; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologau
	2810
	n/a
	ENSG00000175793
	n/a
	P31947
	n/a
	NM_006142
	n/a
	NP_006133
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SFN yw SFN a elwir hefyd yn Stratifin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SFN.

YWHAS

Llyfryddiaeth

"Stratifin accelerates progression of lung adenocarcinoma at an early stage. ". Mol Cancer. 2015. PMID 26223682.
"The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. ". Nat Commun. 2015. PMID 26179207.
"Increase of stratifin triggered by ultraviolet irradiation is possibly related to premature aging of human skin. ". Exp Dermatol. 2014. PMID 25234834.
"Decreased expression of 14-3-3σ is predictive of poor prognosis for patients with human uterine papillary serous carcinoma. ". Tohoku J Exp Med. 2013. PMID 24201220.
"Proteomic analysis reveals important role of 14-3-3σ in anoikis resistance of cholangiocarcinoma cells.". Proteomics. 2013. PMID 24030981.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SFN - Cronfa NCBI

[1]

[2]