SHC1

SHC1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI
Dynodwyr
Cyfenwau	SHC1, SHC, SHCA, SHC adaptor protein 1
Dynodwyr allanol	OMIM: 600560 HomoloGene: 7934 GeneCards: SHC1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• insulin-like growth factor receptor binding; • transmembrane receptor protein tyrosine kinase adaptor activity; • insulin receptor binding; • neurotrophin TRKA receptor binding; • ephrin receptor binding; • epidermal growth factor receptor binding; • receptor tyrosine kinase binding; • GO:0001948, GO:0016582 protein binding; • phospholipid binding; • epidermal growth factor binding; • phosphotyrosine residue binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • mitochondrial matrix; • mitocondria; • Shc-EGFR complex; • Cellbilen;
Prosesau biolegol	• actin cytoskeleton reorganization; • GO:1901047 insulin receptor signaling pathway; • GO:0007243 intracellular signal transduction; • epidermal growth factor receptor signaling pathway; • cellular response to growth factor stimulus; • MAPK cascade; • Fc-epsilon receptor signaling pathway; • heart development; • IRE1-mediated unfolded protein response; • regulation of cell population proliferation; • angiogenesis; • regulation of epidermal growth factor-activated receptor activity; • regulation of growth; • Ras protein signal transduction; • GO:0022415 viral process; • leukocyte migration; • GO:0072468 signal transduction; • ERBB2 signaling pathway; • axon guidance; • defense response to bacterium; • negative regulation of apoptotic process; • positive regulation of MAPK cascade; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of ERK1 and ERK2 cascade; • cell-cell adhesion; • interleukin-15-mediated signaling pathway; • negative regulation of angiogenesis; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • positive regulation of cell proliferation in bone marrow; • regulation of superoxide metabolic process; • positive regulation of cell population proliferation; • positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	6464
	n/a
	ENSG00000160691
	n/a
	P29353
	n/a
	NM_001130040; NM_001130041; NM_001202859; NM_003029; NM_183001
	n/a
	NP_001123512; NP_001123513; NP_001189788; NP_003020; NP_892113
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SHC1 yw SHC1 a elwir hefyd yn SHC adaptor protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SHC1.

SHC
SHCA

Llyfryddiaeth

"Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene. ". Mol Biol Cell. 2014. PMID 24807908.
"Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide. ". Antioxid Redox Signal. 2014. PMID 24766279.
"Nicotine Exposure Augments Renal Toxicity of 5-aza-cytidine Through p66shc: Prevention by Resveratrol. ". Anticancer Res. 2017. PMID 28739690.
"The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. ". Int J Clin Exp Pathol. 2015. PMID 26464652.
"Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endothelial damage.". Hypertension. 2014. PMID 24842918.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SHC1 - Cronfa NCBI

[1]

[2]