SIRT3

SIRT3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3GLR, 3GLS, 3GLU, 4BN4, 4BN5, 4BV3, 4BVB, 4BVE, 4BVF, 4BVG, 4BVH, 4C78, 4C7B, 4FVT, 4FZ3, 4HD8, 4JSR, 4JT8, 4JT9, 4O8Z, 4V1C, 5D7N, 5BWN, 5BWO
Dynodwyr
Cyfenwau	SIRT3, SIR2L3, sirtuin 3
Dynodwyr allanol	OMIM: 604481 HomoloGene: 81827 GeneCards: SIRT3
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• NAD+ ADP-ribosyltransferase activity; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • NAD+ binding; • metal ion binding; • zinc ion binding; • NAD-dependent histone deacetylase activity; • NAD-dependent protein deacetylase activity; • sequence-specific DNA binding; • enzyme binding;
Cydrannau o'r gell	• mitocondria; • mitochondrial matrix; • GO:0009327 protein-containing complex; • cytoplasm; • nucleoplasm;
Prosesau biolegol	• protein deacetylation; • aerobic respiration; • mitochondrion organization; • peptidyl-lysine deacetylation; • protein ADP-ribosylation; • negative regulation of ERK1 and ERK2 cascade; • positive regulation of insulin secretion; • negative regulation of reactive oxygen species metabolic process; • GO:0010260 heneiddio; • histone deacetylation;
	Sources:Amigo / QuickGO
Orthologau
	23410
	n/a
	ENSG00000142082
	n/a
	Q9NTG7
	n/a
	NM_001017524; NM_012239
	n/a
NP_001017524; NP_036371; NP_001357239; NP_001357241; NP_001357243;
	NP_001357244; NP_001357245; NP_001357246; NP_001357247; NP_001357248; NP_001357249; NP_001357250; NP_001357251; NP_001357252; NP_001357253; NP_001357254
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIRT3 yw SIRT3 a elwir hefyd yn Sirtuin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIRT3.

SIR2L3

Llyfryddiaeth[golygu | golygu cod]

"AGEs Decreased SIRT3 Expression and SIRT3 Activation Protected AGEs-Induced EPCs' Dysfunction and Strengthened Anti-oxidant Capacity. ". Inflammation. 2017. PMID 28032248.
"Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells. ". Biochem Biophys Res Commun. 2017. PMID 27856259.
"Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis. ". Oncogene. 2017. PMID 28368421.
"SIRT3 functions as a tumor suppressor in hepatocellular carcinoma. ". Tumour Biol. 2017. PMID 28347248.
"SIRT3 is correlated with the malignancy of non-small cell lung cancer.". Int J Oncol. 2017. PMID 28197634.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] SIRT3 - Cronfa NCBI

[1]

[2]