SLBP

SLBP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2KJM, 4QOZ
Dynodwyr
Cyfenwau	SLBP, HBP, stem-loop binding protein
Dynodwyr allanol	OMIM: 602422 HomoloGene: 31389 GeneCards: SLBP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• histone pre-mRNA DCP binding; • histone pre-mRNA stem-loop binding; • GO:0001948, GO:0016582 protein binding; • mRNA binding; • RNA binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • histone pre-mRNA 3'end processing complex; • nucleoplasm; • cnewyllyn cell; • nucleolus; • cytosol; • ribonucleoprotein complex;
Prosesau biolegol	• termination of RNA polymerase II transcription; • mRNA transport; • mRNA 3'-end processing by stem-loop binding and cleavage; • mRNA processing; • mRNA export from nucleus; • nuclear DNA replication; • histone mRNA metabolic process; • cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	7884
	n/a
	ENSG00000163950
	n/a
	Q14493; Q53XR2
	n/a
	NM_001306074; NM_001306075; NM_006527
	n/a
	NP_001293003; NP_001293004; NP_006518; NP_006518.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLBP yw SLBP a elwir hefyd yn Histone RNA hairpin-binding protein a Stem-loop (Histone) binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p16.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLBP.

HBP

Llyfryddiaeth

"Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression. ". J Biol Chem. 2014. PMID 25266719.
"Translation regulation and proteasome mediated degradation cooperate to keep stem-loop binding protein low in G1-phase. ". J Cell Biochem. 2014. PMID 24122909.
"Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation. ". PLoS One. 2017. PMID 28306745.
"Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. ". J Clin Invest. 2016. PMID 27454292.
"A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA.". Biol Trace Elem Res. 2015. PMID 25893362.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SLBP - Cronfa NCBI

[1]

[2]