SLIT2

SLIT2
Strwythurau
PDB	Human UniProt search: H0Y9Z6 PDBe H0Y9Z6 RCSB
Rhestr o ddynodwyr PDB
	2V70, 2V9S, 2V9T, 2WFH
Dynodwyr
Cyfenwau	SLIT2, SLIL3, Slit-2, slit guidance ligand 2
Dynodwyr allanol	OMIM: 603746 HomoloGene: 3516 GeneCards: SLIT2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • heparin binding; • protein homodimerization activity; • GTPase inhibitor activity; • laminin-1 binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • Roundabout binding; • proteoglycan binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • extracellular region; • cell surface; • extracellular exosome; • Cellbilen; • extracellular space;
Prosesau biolegol	• GO:0033128 negative regulation of protein phosphorylation; • negative regulation of chemokine-mediated signaling pathway; • negative regulation of neutrophil chemotaxis; • negative regulation of cellular response to growth factor stimulus; • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; • cell differentiation; • ureteric bud development; • negative chemotaxis; • negative regulation of actin filament polymerization; • negative regulation of small GTPase mediated signal transduction; • negative regulation of retinal ganglion cell axon guidance; • negative regulation of mononuclear cell migration; • corticospinal neuron axon guidance through spinal cord; • negative regulation of smooth muscle cell migration; • Roundabout signaling pathway; • positive regulation of axonogenesis; • nervous system development; • cell migration involved in sprouting angiogenesis; • negative regulation of endothelial cell migration; • axon guidance; • multicellular organism development; • chemotaxis; • negative regulation of smooth muscle cell chemotaxis; • cellular response to hormone stimulus; • negative regulation of cell migration; • negative regulation of monocyte chemotaxis; • negative regulation of cell growth; • response to cortisol; • apoptotic process involved in luteolysis; • positive regulation of apoptotic process; • induction of negative chemotaxis; • cellular response to heparin; • motor neuron axon guidance; • branching morphogenesis of an epithelial tube; • negative regulation of leukocyte chemotaxis; • chemorepulsion involved in postnatal olfactory bulb interneuron migration; • axon extension involved in axon guidance; • negative regulation of lamellipodium assembly; • negative regulation of vascular permeability; • retinal ganglion cell axon guidance; • GO:0034259 negative regulation of GTPase activity; • aortic valve morphogenesis; • pulmonary valve morphogenesis; • ventricular septum morphogenesis;
	Sources:Amigo / QuickGO
Orthologau
	9353
	n/a
	ENSG00000145147
	n/a
	O94813
	n/a
	NM_001289135; NM_001289136; NM_004787
	n/a
	NP_001276064; NP_001276065; NP_004778
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLIT2 yw SLIT2 a elwir hefyd yn Slit homolog 2 protein a Slit guidance ligand 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLIT2.

SLIL3
Slit-2

Llyfryddiaeth

"Slit2 exerts anti-inflammatory actions in human placenta and is decreased with maternal obesity. ". Am J Reprod Immunol. 2015. PMID 25329354.
"Slit2 is decreased after spontaneous labour in myometrium and regulates pro-labour mediators. ". J Reprod Immunol. 2014. PMID 25130654.
"The differential roles of Slit2-exon 15 splicing variants in angiogenesis and HUVEC permeability. ". Angiogenesis. 2015. PMID 26021305.
"Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling. ". Cell Death Dis. 2015. PMID 25590802.
"Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.". Proc Natl Acad Sci U S A. 2014. PMID 25489114.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SLIT2 - Cronfa NCBI

[1]

[2]