SMAD3

SMAD3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Dynodwyr
Cyfenwau	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Dynodwyr allanol	OMIM: 603109 HomoloGene: 55937 GeneCards: SMAD3
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phosphatase binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • R-SMAD binding; • co-SMAD binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • transcription factor binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • enzyme binding; • transforming growth factor beta receptor binding; • protein homodimerization activity; • collagen binding; • zinc ion binding; • chromatin binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • double-stranded DNA binding; • protein kinase binding; • sequence-specific DNA binding; • DNA binding; • bHLH transcription factor binding; • ubiquitin binding; • identical protein binding; • protein heterodimerization activity; • chromatin DNA binding; • ubiquitin protein ligase binding; • beta-catenin binding; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • DEAD/H-box RNA helicase binding; • mineralocorticoid receptor binding; • glucocorticoid receptor binding; • primary miRNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • SMAD binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001104 transcription coregulator activity;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • heteromeric SMAD protein complex; • SMAD protein complex; • transcription regulator complex; • receptor complex; • Cellbilen; • intracellular anatomical structure; • nucleoplasm; • nuclear inner membrane; • cytosol; • GO:0009327 protein-containing complex;
Prosesau biolegol	• somitogenesis; • skeletal system development; • ureteric bud development; • endoderm development; • regulation of transforming growth factor beta2 production; • embryonic pattern specification; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of osteoblast differentiation; • heart looping; • positive regulation of chondrocyte differentiation; • positive regulation of alkaline phosphatase activity; • positive regulation of interleukin-1 beta production; • pericardium development; • regulation of binding; • negative regulation of wound healing; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • transforming growth factor beta receptor signaling pathway; • negative regulation of inflammatory response; • positive regulation of positive chemotaxis; • negative regulation of cell population proliferation; • negative regulation of fat cell differentiation; • cell-cell junction organization; • GO:0009373 regulation of transcription, DNA-templated; • extrinsic apoptotic signaling pathway; • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • signal transduction involved in regulation of gene expression; • in utero embryonic development; • negative regulation of transforming growth factor beta receptor signaling pathway; • nodal signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of cell growth; • regulation of immune response; • positive regulation of transforming growth factor beta3 production; • T cell activation; • activin receptor signaling pathway; • regulation of striated muscle tissue development; • embryonic foregut morphogenesis; • positive regulation of bone mineralization; • wound healing; • negative regulation of apoptotic process; • positive regulation of extracellular matrix assembly; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of epithelial to mesenchymal transition; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • thyroid gland development; • developmental growth; • lens fiber cell differentiation; • gastrulation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • osteoblast differentiation; • GO:1990744, GO:1990729 primary miRNA processing; • negative regulation of osteoblast proliferation; • osteoblast development; • embryonic cranial skeleton morphogenesis; • transdifferentiation; • paraxial mesoderm morphogenesis; • response to hypoxia; • positive regulation of cell migration; • mesoderm formation; • regulation of transforming growth factor beta receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • immune system development; • positive regulation of focal adhesion assembly; • liver development; • regulation of epithelial cell proliferation; • positive regulation of stress fiber assembly; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of mitotic cell cycle; • negative regulation of cytosolic calcium ion concentration; • canonical Wnt signaling pathway; • protein stabilization; • transcription, DNA-templated; • GO:1903363 negative regulation of protein catabolic process; • protein deubiquitination; • positive regulation of nitric oxide biosynthetic process; • negative regulation of lung blood pressure; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of cardiac muscle hypertrophy in response to stress; • cellular response to transforming growth factor beta stimulus; • cellular response to cytokine stimulus; • positive regulation of protein import into nucleus; • positive regulation of DNA-binding transcription factor activity; • SMAD protein signal transduction; • positive regulation of canonical Wnt signaling pathway; • SMAD protein complex assembly; • adrenal gland development;
	Sources:Amigo / QuickGO
Orthologau
	4088
	n/a
	ENSG00000166949
	n/a
	P84022
	n/a
	NM_001145102; NM_001145103; NM_001145104; NM_005902
	n/a
	NP_001138574; NP_001138575; NP_001138576; NP_005893
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD3 yw SMAD3 a elwir hefyd yn SMAD family member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD3.

LDS3
LDS1C
MADH3
JV15-2
HSPC193
HsT17436

Llyfryddiaeth

"The SMAD3 transcription factor binds complex RNA structures with high affinity. ". Nucleic Acids Res. 2017. PMID 29036649.
"Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3. ". Biochem Biophys Res Commun. 2017. PMID 28450107.
"Endovascular Repair of Internal Mammary Artery Aneurysms in 2 Sisters with SMAD3 Mutation. ". Ann Vasc Surg. 2017. PMID 28286188.
"Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers. ". J Allergy Clin Immunol. 2017. PMID 28011059.
"SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?". Biol Reprod. 2016. PMID 27683263.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SMAD3 - Cronfa NCBI

[1]

[2]