SMAD7 |
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Dynodwyr |
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Cyfenwau | SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7 |
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Dynodwyr allanol | OMIM: 602932 HomoloGene: 4314 GeneCards: SMAD7 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • DNA binding • beta-catenin binding • type I transforming growth factor beta receptor binding • collagen binding • I-SMAD binding • activin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Cydrannau o'r gell | • cytoplasm • centrosome • transcription regulator complex • Cellbilen • intracellular anatomical structure • nucleoplasm • catenin complex • cnewyllyn cell • fibrillar center • cytosol • GO:0009327 protein-containing complex
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Prosesau biolegol | • cellular response to transforming growth factor beta stimulus • regulation of ventricular cardiac muscle cell membrane depolarization • pathway-restricted SMAD protein phosphorylation • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • adherens junction assembly • positive regulation of cell-cell adhesion • ventricular septum morphogenesis • regulation of epithelial to mesenchymal transition • negative regulation of peptidyl-threonine phosphorylation • negative regulation of transcription by competitive promoter binding • response to laminar fluid shear stress • protein stabilization • regulation of activin receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of DNA-binding transcription factor activity • negative regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of BMP signaling pathway • ventricular cardiac muscle tissue morphogenesis • negative regulation of protein ubiquitination • negative regulation of cell migration • negative regulation of ubiquitin-protein transferase activity • artery morphogenesis • negative regulation of peptidyl-serine phosphorylation • regulation of cardiac muscle contraction • positive regulation of protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of epithelial to mesenchymal transition • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of transforming growth factor beta receptor signaling pathway • transcription, DNA-templated • transforming growth factor beta receptor signaling pathway • protein deubiquitination • negative regulation of T cell cytokine production • negative regulation of T-helper 17 type immune response • negative regulation of T-helper 17 cell differentiation • cellular response to leukemia inhibitory factor
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD7 yw SMAD7 a elwir hefyd yn SMAD family member 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD7.
- "The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis. ". BMC Med Genet. 2017. PMID 29084532.
- "MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia. ". Gene. 2017. PMID 28732737.
- "Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death. ". Cell Death Dis. 2017. PMID 28300830.
- "High Smad7 sustains inflammatory cytokine response in refractory coeliac disease. ". Immunology. 2017. PMID 27861825.
- "SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population.". Oncotarget. 2016. PMID 26989026.