SMG6

SMG6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2DOK, 2HWW, 2HWX, 4UM2
Dynodwyr
Cyfenwau	SMG6, C17orf31, EST1A, SMG-6, hSMG5/7a, nonsense mediated mRNA decay factor, SMG6 nonsense mediated mRNA decay factor, hEST1A
Dynodwyr allanol	OMIM: 610963 HomoloGene: 23024 GeneCards: SMG6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • telomeric DNA binding; • metal ion binding; • DNA polymerase binding; • GO:0001948, GO:0016582 protein binding; • nuclease activity; • endonuclease activity; • hydrolase activity; • telomerase RNA binding; • endoribonuclease activity; • RNA binding; • ribonucleoprotein complex binding; • ribonuclease activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • exon-exon junction complex; • Cromosom; • telomere; • telomerase catalytic core complex; • nucleolus; • telomerase holoenzyme complex; • cnewyllyn cell;
Prosesau biolegol	• nucleic acid phosphodiester bond hydrolysis; • mRNA export from nucleus; • negative regulation of telomere capping; • regulation of dephosphorylation; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • RNA phosphodiester bond hydrolysis, endonucleolytic; • regulation of RNA stability; • regulation of telomere maintenance; • regulation of telomere maintenance via telomerase; • regulation of telomerase activity; • telomere maintenance via telomerase; • RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologau
	23293
	n/a
	ENSG00000070366
	n/a
	Q86US8
	n/a
	NM_001170957; NM_001256827; NM_001256828; NM_001282326; NM_017575
	n/a
	NP_001243756; NP_001243757; NP_001269255; NP_060045
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMG6 yw SMG6 a elwir hefyd yn Telomerase-binding protein EST1A a SMG6, nonsense mediated mRNA decay factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMG6.

EST1A
SMG-6
C17orf31
hSMG5/7a

Llyfryddiaeth

"Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer. ". Genomics. 2000. PMID 11087658.
"Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. ". RNA. 2017. PMID 28461625.
"Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. ". Nucleic Acids Res. 2015. PMID 25429978.
"Crystal structure of the PIN domain of human telomerase-associated protein EST1A. ". Proteins. 2007. PMID 17557331.
"Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID 16820686.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SMG6 - Cronfa NCBI

[1]

[2]