SNAP25

SNAP25
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KIL, 1XTG, 3DDA, 3RK2, 3RK3, 3RL0, 3ZUR, 2N1T, 3DDB
Dynodwyr
Cyfenwau	SNAP25, CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2, SUP, synaptosome associated protein 25kDa, synaptosome associated protein 25
Dynodwyr allanol	OMIM: 600322 HomoloGene: 13311 GeneCards: SNAP25
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• SNAP receptor activity; • calcium-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • SNARE binding; • syntaxin-1 binding; • voltage-gated potassium channel activity; • syntaxin binding;
Cydrannau o'r gell	• cytoplasm; • fesigl; • cytosol; • bilen; • growth cone; • myelin sheath; • BLOC-1 complex; • voltage-gated potassium channel complex; • Cellbilen; • synapse; • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; • cell junction; • trans-Golgi network; • SNARE complex; • perinuclear region of cytoplasm; • neuron projection; • synaptic vesicle; • presynaptic membrane; • axon; • specific granule membrane; • somatodendritic compartment; • tertiary granule membrane; • postsynapse; • extrinsic component of cytoplasmic side of plasma membrane; • Cytosgerbwd; • glutamatergic synapse;
Prosesau biolegol	• associative learning; • regulation of neuron projection development; • synaptic vesicle docking; • locomotory behavior; • regulation of insulin secretion; • synaptic vesicle exocytosis; • synaptic vesicle fusion to presynaptic active zone membrane; • glutamate secretion; • neurotransmitter uptake; • synaptic vesicle priming; • regulation of establishment of protein localization; • GO:0010554 neurotransmitter secretion; • long-term potentiation; • chemical synaptic transmission; • positive regulation of synaptic plasticity; • neutrophil degranulation; • short-term synaptic potentiation; • exocytic insertion of neurotransmitter receptor to postsynaptic membrane; • neurotransmitter receptor internalization; • exocytosis; • vesicle fusion; • potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologau
	6616
	n/a
	ENSG00000132639
	n/a
	P60880
	n/a
NM_003081; NM_130811; NM_001322902; NM_001322903; NM_001322904;
	NM_001322905; NM_001322906; NM_001322907; NM_001322908; NM_001322909; NM_001322910
	n/a
NP_001309831; NP_001309832; NP_001309833; NP_001309834; NP_001309835;
	NP_001309836; NP_001309837; NP_001309838; NP_001309839; NP_003072; NP_570824
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SNAP25 yw SNAP25 a elwir hefyd yn Synaptosome associated protein 25 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p12.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SNAP25.

SUP
RIC4
SEC9
SNAP
CMS18
RIC-4
SNAP-25
bA416N4.2
dJ1068F16.2

Llyfryddiaeth

"A Multilevel Functional Study of a SNAP25At-Risk Variant for Bipolar Disorder and Schizophrenia. ". J Neurosci. 2017. PMID 28972123.
"Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma. ". Int J Mol Med. 2017. PMID 28339008.
"Synaptosome-Associated Protein 25 (SNAP25) Gene Association Analysis Revealed Risk Variants for ASD, in Iranian Population. ". J Mol Neurosci. 2017. PMID 27888397.
"SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population. ". Neurol Res. 2016. PMID 27627841.
"Two SNAP-25 genetic variants in the binding site of multiple microRNAs and susceptibility of ADHD: A meta-analysis.". J Psychiatr Res. 2016. PMID 27380186.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SNAP25 - Cronfa NCBI

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[2]