SOCS2

SOCS2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2C9W, 4JGH, 5BO4
Dynodwyr
Cyfenwau	SOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
Dynodwyr allanol	OMIM: 605117 HomoloGene: 2880 GeneCards: SOCS2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• insulin-like growth factor receptor binding; • protein kinase inhibitor activity; • JAK pathway signal transduction adaptor activity; • GO:0001948, GO:0016582 protein binding; • growth hormone receptor binding; • 1-phosphatidylinositol-3-kinase regulator activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • phosphatidylinositol 3-kinase complex;
Prosesau biolegol	• receptor signaling pathway via JAK-STAT; • response to estradiol; • GO:0007243 intracellular signal transduction; • negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • negative regulation of apoptotic process; • GO:1903105 negative regulation of insulin receptor signaling pathway; • cellular response to hormone stimulus; • growth hormone receptor signaling pathway; • regulation of signal transduction; • regulation of cell growth; • protein ubiquitination; • regulation of growth; • negative regulation of signal transduction; • negative regulation of receptor signaling pathway via JAK-STAT; • positive regulation of signal transduction; • lactation; • regulation of multicellular organism growth; • negative regulation of multicellular organism growth; • post-translational protein modification; • positive regulation of neuron differentiation; • mammary gland alveolus development; • interleukin-7-mediated signaling pathway; • regulation of phosphatidylinositol 3-kinase activity; • phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	8835
	n/a
	ENSG00000120833
	n/a
	O14508
	n/a
NM_001270467; NM_001270468; NM_001270469; NM_001270470; NM_001270471;
	NM_003877
	n/a
NP_001257396; NP_001257397; NP_001257398; NP_001257399; NP_001257400;
	NP_003868
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOCS2 yw SOCS2 a elwir hefyd yn Suppressor of cytokine signaling 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOCS2.

CIS2
SSI2
Cish2
SSI-2
SOCS-2
STATI2

Llyfryddiaeth

"Suppressor of Cytokine Signaling-2 (SOCS2) Regulates the Microglial Response and Improves Functional Outcome after Traumatic Brain Injury in Mice. ". PLoS One. 2016. PMID 27071013.
"SOCS2: physiological and pathological functions. ". Front Biosci (Elite Ed). 2016. PMID 26709655.
"A herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer. ". Tumour Biol. 2017. PMID 28468588.
"GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2. ". Mol Cell Endocrinol. 2017. PMID 27566229.
"The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma.". Tumour Biol. 2016. PMID 27465557.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SOCS2 - Cronfa NCBI

[1]

[2]