SOD1

SOD1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7, 1SOS, 1SPD, 1UXL, 1UXM, 2AF2, 2C9S, 2C9U, 2C9V, 2GBT, 2GBU, 2GBV, 2LU5, 2MP3, 2NNX, 2R27, 2V0A, 2VR6, 2VR7, 2VR8, 2WKO, 2WYT, 2WYZ, 2WZ0, 2WZ5, 2WZ6, 2XJK, 2XJL, 2ZKW, 2ZKX, 2ZKY, 3CQP, 3CQQ, 3ECU, 3ECV, 3ECW, 3GQF, 3GTV, 3GZO, 3GZP, 3GZQ, 3H2P, 3H2Q, 3HFF, 3K91, 3KH3, 3KH4, 3LTV, 3QQD, 3RE0, 3T5W, 4A7G, 4A7Q, 4A7S, 4A7T, 4A7U, 4A7V, 4B3E, 4BCY, 4BCZ, 4BD4, 4FF9, 4MCM, 4MCN, 4NIN, 4NIP, 4OH2, 4XCR
Dynodwyr
Cyfenwau	SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP
Dynodwyr allanol	OMIM: 147450 HomoloGene: 392 GeneCards: SOD1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • enzyme binding; • oxidoreductase activity; • superoxide dismutase activity; • protein homodimerization activity; • zinc ion binding; • GO:0001948, GO:0016582 protein binding; • copper ion binding; • protein phosphatase 2B binding; • chaperone binding; • antioxidant activity; • identical protein binding; • superoxide dismutase copper chaperone activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • mitochondrial intermembrane space; • extracellular region; • mitocondria; • neuron projection; • dendrite cytoplasm; • dense core granule; • cnewyllyn cell; • myelin sheath; • peroxisome; • lysosome; • extracellular exosome; • GO:0005578 extracellular matrix; • Cellbilen; • secretory granule; • nucleoplasm; • soma; • mitochondrial matrix; • GO:0016023 cytoplasmic vesicle; • axon cytoplasm; • extracellular space; • GO:0009327 protein-containing complex;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • muscle cell cellular homeostasis; • response to copper ion; • placenta development; • response to amphetamine; • GO:0048554 positive regulation of catalytic activity; • response to heat; • response to organic substance; • anterograde axonal transport; • spermatogenesis; • response to ethanol; • neurofilament cytoskeleton organization; • heart contraction; • embryo implantation; • locomotory behavior; • thymus development; • removal of superoxide radicals; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • transmission of nerve impulse; • GO:1904576 response to antibiotic; • myeloid cell homeostasis; • GO:0001306 response to oxidative stress; • reactive oxygen species metabolic process; • regulation of T cell differentiation in thymus; • retina homeostasis; • response to nutrient levels; • hydrogen peroxide biosynthetic process; • regulation of protein kinase activity; • negative regulation of cholesterol biosynthetic process; • cellular response to potassium ion; • retrograde axonal transport; • glutathione metabolic process; • response to antipsychotic drug; • negative regulation of apoptotic process; • cellular response to cadmium ion; • response to carbon monoxide; • regulation of blood pressure; • response to axon injury; • relaxation of vascular associated smooth muscle; • ovarian follicle development; • cellular response to ATP; • response to hydrogen peroxide; • superoxide metabolic process; • peripheral nervous system myelin maintenance; • response to superoxide; • GO:0032737 positive regulation of cytokine production; • regulation of multicellular organism growth; • GO:0010260 heneiddio; • platelet degranulation; • clyw; • superoxide anion generation; • auditory receptor cell stereocilium organization; • regulation of mitochondrial membrane potential; • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • positive regulation of apoptotic process; • positive regulation of superoxide anion generation; • regulation of organ growth; • cellular iron ion homeostasis; • GO:0001315 response to reactive oxygen species; • cellular response to oxidative stress; • interleukin-12-mediated signaling pathway; • negative regulation of inflammatory response; • positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologau
	6647
	n/a
	ENSG00000142168
	n/a
	P00441
	n/a
	NM_000454
	n/a
	NP_000445
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOD1 yw SOD1 a elwir hefyd yn Superoxide dismutase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOD1.

ALS
SOD
ALS1
IPOA
hSod1
HEL-S-44
homodimer

Llyfryddiaeth

"Improving glycemic control in model mice with type 2 diabetes by increasing superoxide dismutase (SOD) activity using silk fibroin hydrolysate (SFH). ". Biochem Biophys Res Commun. 2017. PMID 28919426.
"Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells. ". PLoS One. 2017. PMID 28877271.
"SOD1G93A Mutant Mice Develop a Neuroinflammation-Independent Dendropathy in Excitatory Neuronal Subsets of the Olfactory Bulb and Retina. ". J Neuropathol Exp Neurol. 2017. PMID 28859334.
"A prion-like mechanism for the propagated misfolding of SOD1 from in silico modeling of solvated near-native conformers. ". PLoS One. 2017. PMID 28472188.
"Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.". Protein Cell. 2017. PMID 28447293.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SOD1 - Cronfa NCBI

[1]

[2]