SOD2

SOD2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AP5, 1AP6, 1EM1, 1JA8, 1LUV, 1LUW, 1MSD, 1N0J, 1N0N, 1PL4, 1PM9, 1QNM, 1SZX, 1VAR, 1XDC, 1XIL, 1ZSP, 1ZTE, 1ZUQ, 2ADP, 2ADQ, 2GDS, 2P4K, 2QKA, 2QKC, 3C3S, 3C3T
Dynodwyr
Cyfenwau	SOD2, IPOB, MNSOD, MVCD6, IPO-B, Mn-SOD, superoxide dismutase 2, mitochondrial, superoxide dismutase 2, GClnc1
Dynodwyr allanol	OMIM: 147460 HomoloGene: 530 GeneCards: SOD2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• superoxide dismutase activity; • manganese ion binding; • metal ion binding; • identical protein binding; • oxidoreductase activity;
Cydrannau o'r gell	• mitocondria; • extracellular exosome; • mitochondrial matrix;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • response to superoxide; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • removal of superoxide radicals; • acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; • regulation of blood pressure; • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; • protein homotetramerization; • oxygen homeostasis; • release of cytochrome c from mitochondria; • superoxide metabolic process; • negative regulation of cell population proliferation; • positive regulation of cell migration; • mitochondrion organization; • cellular response to oxidative stress; • interleukin-12-mediated signaling pathway; • GO:0010260 heneiddio; • negative regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell apoptotic process; • positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;
	Sources:Amigo / QuickGO
Orthologau
	6648
	n/a
	ENSG00000112096
	n/a
	P04179
	n/a
NM_000636; NM_001024465; NM_001024466; NM_001322814; NM_001322815;
	NM_001322816; NM_001322817; NM_001322819; NM_001322820
	n/a
NP_000627; NP_001019636; NP_001019637; NP_001309743; NP_001309744;
	NP_001309745; NP_001309746; NP_001309748; NP_001309749
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOD2 yw SOD2 a elwir hefyd yn Superoxide dismutase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOD2.

IPOB
IPO-B
MNSOD
MVCD6
Mn-SOD

Llyfryddiaeth

"ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels. ". Gene. 2017. PMID 28552711.
"Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals. ". Acta Crystallogr F Struct Biol Commun. 2017. PMID 28368283.
"Role for Functional SOD2 Polymorphism in Pulmonary Arterial Hypertension in a Chinese Population. ". Int J Environ Res Public Health. 2017. PMID 28272301.
"Polymorphism variant of MnSOD A16V and risk of female infertility in northern Iran. ". Taiwan J Obstet Gynecol. 2016. PMID 28040123.
"Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy.". Biomed Pharmacother. 2017. PMID 27923686.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SOD2 - Cronfa NCBI

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