SPARC

SPARC
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BMO, 1NUB, 1SRA, 2V53
Dynodwyr
Cyfenwau	SPARC, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
Dynodwyr allanol	OMIM: 182120 HomoloGene: 31132 GeneCards: SPARC
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • extracellular matrix binding; • collagen binding; • extracellular matrix structural constituent;
Cydrannau o'r gell	• cytoplasm; • platelet alpha granule; • endocytic vesicle lumen; • nuclear matrix; • Cellbilen; • intracellular anatomical structure; • basement membrane; • cell surface; • platelet alpha granule membrane; • mitocondria; • platelet alpha granule lumen; • cnewyllyn cell; • extracellular space; • fesigl; • extracellular region; • GO:0005578 extracellular matrix; • synapse; • collagen-containing extracellular matrix; • glutamatergic synapse;
Prosesau biolegol	• response to cytokine; • response to cadmium ion; • ossification; • lung development; • cellular response to growth factor stimulus; • response to peptide hormone; • platelet degranulation; • extracellular matrix organization; • response to L-ascorbic acid; • response to glucocorticoid; • wound healing; • receptor-mediated endocytosis; • negative regulation of endothelial cell proliferation; • positive regulation of endothelial cell migration; • response to calcium ion; • response to gravity; • heart development; • response to lipopolysaccharide; • response to lead ion; • regulation of cell population proliferation; • negative regulation of angiogenesis; • inner ear development; • regulation of cell morphogenesis; • response to cAMP; • response to ethanol; • bone development; • GO:0072468 signal transduction; • pigmentation; • GO:1904739 regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologau
	6678
	n/a
	ENSG00000113140
	n/a
	P09486
	n/a
	NM_003118; NM_001309443; NM_001309444
	n/a
	NP_001296372; NP_001296373; NP_003109
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPARC yw SPARC a elwir hefyd yn Secreted protein acidic and cysteine rich (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPARC.

ON
OI17
BM-40

Llyfryddiaeth

"Clinical significance of SPARC in esophageal squamous cell carcinoma. ". Biochem Biophys Res Commun. 2017. PMID 28818666.
"The relationship between SPARC expression in primary tumor and metastatic lymph node of resected pancreatic cancer patients and patients' survival. ". Hepatobiliary Pancreat Dis Int. 2017. PMID 28119265.
"In phyllodes tumors of the breast expression of SPARC (osteonectin/BM40) mRNA by in situ hybridization correlates with protein expression by immunohistochemistry and is associated with tumor progression. ". Virchows Arch. 2017. PMID 27909812.
"The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease. ". Br J Pharmacol. 2017. PMID 27759879.
"Prognostic Value of SPARC in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis.". PLoS One. 2016. PMID 26731428.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SPARC - Cronfa NCBI

[1]

[2]