SPTB

SPTB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1S35, 3EDU, 3F57, 3KBT, 3KBU, 3LBX
Dynodwyr
Cyfenwau	SPTB, EL3, HS2, HSPTB1, SPH2, spectrin beta, erythrocytic
Dynodwyr allanol	OMIM: 182870 HomoloGene: 295 GeneCards: SPTB
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• actin filament binding; • structural constituent of cytoskeleton; • GO:0001948, GO:0016582 protein binding; • ankyrin binding; • actin binding;
Cydrannau o'r gell	• spectrin; • intrinsic component of the cytoplasmic side of the plasma membrane; • cell surface; • cell cortex; • actin cytoskeleton; • spectrin-associated cytoskeleton; • Cytosgerbwd; • cytoplasm; • Golgi apparatus; • cytosol; • GO:0009327 protein-containing complex;
Prosesau biolegol	• MAPK cascade; • axon guidance; • endoplasmic reticulum to Golgi vesicle-mediated transport; • actin filament capping; • cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologau
	6710
	n/a
	ENSG00000070182
	n/a
	P11277
	n/a
	NM_000347; NM_001024858; NM_001355436; NM_001355437
	n/a
	NP_001020029; NP_001342365; NP_001342366
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPTB yw SPTB a elwir hefyd yn Spectrin beta chain, erythrocytic a Spectrin beta, erythrocytic (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPTB.

EL3
HS2
SPH2
HSPTB1

Llyfryddiaeth

"ATP-dependent mechanism protects spectrin against glycation in human erythrocytes. ". J Biol Chem. 2010. PMID 20724481.
"The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties. ". Blood. 2009. PMID 19168783.
"Targeted next generation sequencing identifies a novel β-spectrin gene mutation A2059P in two Omani children with hereditary pyropoikilocytosis. ". Am J Hematol. 2017. PMID 28699249.
"A new frameshift mutation of the β-spectrin gene associated with hereditary spherocytosis. ". Ann Hematol. 2017. PMID 27709257.
"Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin.". PLoS One. 2011. PMID 21738695.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SPTB - Cronfa NCBI

[1]

[2]