SRF |
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Dynodwyr |
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Cyfenwau | SRF, MCM1, serum response factor |
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Dynodwyr allanol | OMIM: 600589 HomoloGene: 31135 GeneCards: SRF |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000983 RNA polymerase II general transcription initiation factor activity • primary miRNA binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein homodimerization activity • serum response element binding • chromatin binding • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding • RNA polymerase II-specific DNA-binding transcription factor binding
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Cydrannau o'r gell | • cytoplasm • cnewyllyn cell • nucleoplasm
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Prosesau biolegol | • dorsal aorta morphogenesis • bronchus cartilage development • muscle cell cellular homeostasis • lung smooth muscle development • regulation of water loss via skin • transcription by RNA polymerase II • stress fiber assembly • cell migration involved in sprouting angiogenesis • platelet activation • cardiac myofibril assembly • heart looping • cellular senescence • face development • regulation of cell adhesion • long-term depression • neuron projection development • morphogenesis of an epithelial sheet • positive regulation of filopodium assembly • primitive streak formation • cellular response to glucose stimulus • negative regulation of cell population proliferation • response to cytokine • GO:0009373 regulation of transcription, DNA-templated • heart trabecula formation • actin filament organization • thymus development • angiogenesis involved in wound healing • platelet formation • neuron development • in utero embryonic development • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • positive regulation of cell differentiation • branching involved in blood vessel morphogenesis • positive regulation of axon extension • positive regulation of smooth muscle contraction • trachea cartilage development • response to toxic substance • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of transcription by glucose • regulation of smooth muscle cell differentiation • epithelial structure maintenance • associative learning • skin morphogenesis • positive regulation of DNA-binding transcription factor activity • epithelial cell-cell adhesion • neuron migration • positive regulation of transcription initiation from RNA polymerase II promoter • eyelid development in camera-type eye • thyroid gland development • negative regulation of amyloid-beta clearance • negative regulation of cell migration • developmental growth • hematopoietic stem cell differentiation • gastrulation • trophectodermal cell differentiation • positive thymic T cell selection • response to hormone • cell-matrix adhesion • sarcomere organization • actin cytoskeleton organization • megakaryocyte development • response to hypoxia • lung morphogenesis • mesoderm formation • cardiac vascular smooth muscle cell differentiation • mRNA transcription by RNA polymerase II • multicellular organism development • tangential migration from the subventricular zone to the olfactory bulb • long-term memory • contractile actin filament bundle assembly • bicellular tight junction assembly • leukocyte differentiation • hippocampus development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • erythrocyte development • negative regulation of pri-miRNA transcription by RNA polymerase II • forebrain development • cell-cell adhesion
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn SRF yw SRF a elwir hefyd yn Serum response factor a Serum response factor (C-fos serum response element-binding transcription factor), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SRF.
- "Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma. ". Int J Oncol. 2014. PMID 24173109.
- "Expression of serum response factor in gastric carcinoma and its molecular mechanisms involved in the regulation of the invasion and migration of SGC-7901 cells. ". Cancer Biother Radiopharm. 2013. PMID 23134219.
- "The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation. ". BMC Cancer. 2017. PMID 28249598.
- "The regulatory role of serum response factor pathway in neutrophil inflammatory response. ". Curr Opin Hematol. 2015. PMID 25402621.
- "The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases.". Prostate. 2014. PMID 24249383.