STAT5A

STAT5A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Y1U
Dynodwyr
Cyfenwau	STAT5A, MGF, STAT5, signal transducer and activator of transcription 5A
Dynodwyr allanol	OMIM: 601511 HomoloGene: 20680 GeneCards: STAT5A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • protein tyrosine kinase activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cnewyllyn cell; • nucleoplasm; • cytoplasm; • cytosol;
Prosesau biolegol	• creatinine metabolic process; • positive regulation of endothelial cell proliferation; • receptor signaling pathway via JAK-STAT; • transcription, DNA-templated; • GO:0072468 signal transduction; • valine metabolic process; • creatine metabolic process; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • positive regulation of blood vessel endothelial cell migration; • fatty acid metabolic process; • taurine metabolic process; • succinate metabolic process; • regulation of multicellular organism growth; • citrate metabolic process; • oxaloacetate metabolic process; • GO:0009373 regulation of transcription, DNA-templated; • allantoin metabolic process; • isoleucine metabolic process; • lactation; • 2-oxoglutarate metabolic process; • peptidyl-tyrosine phosphorylation; • interleukin-7-mediated signaling pathway; • growth hormone receptor signaling pathway via JAK-STAT; • interleukin-15-mediated signaling pathway; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • reelin-mediated signaling pathway; • defense response; • regulation of cell population proliferation; • response to peptide hormone; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	6776
	n/a
	ENSG00000126561
	n/a
	P42229
	n/a
	NM_001288718; NM_001288719; NM_001288720; NM_003152
	n/a
	NP_001275647; NP_001275648; NP_001275649; NP_003143
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT5A yw STAT5A a elwir hefyd yn Signal transducer and activator of transcription 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STAT5A.

MGF
STAT5

Llyfryddiaeth

"Epigenetic regulation of STAT5A and its role as fetal DNA epigenetic marker during placental development and dysfunction. ". Placenta. 2016. PMID 27452437.
"Signal transducer and activator of transcription 5 is implicated in disease activity in adult and juvenile onset systemic lupus erythematosus. ". Clin Rheumatol. 2016. PMID 27041383.
"Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex. ". PLoS Pathog. 2017. PMID 28459842.
"STAT5 phosphorylation in CD4 T cells from patients with SLE is related to changes in their subsets and follow-up disease severity. ". J Leukoc Biol. 2017. PMID 28254841.
"O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.". Leukemia. 2017. PMID 28074064.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] STAT5A - Cronfa NCBI

[1]

[2]