STAT5B

STAT5B
Dynodwyr
Cyfenwau	STAT5B, STAT5, signal transducer and activator of transcription 5B, GHISID2
Dynodwyr allanol	OMIM: 604260 HomoloGene: 55718 GeneCards: STAT5B
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signal transducer activity; • glucocorticoid receptor binding; • protein dimerization activity; • chromatin binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• nucleoplasm; • cytoplasm; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• positive regulation of natural killer cell differentiation; • positive regulation of natural killer cell mediated cytotoxicity; • regulation of steroid metabolic process; • creatinine metabolic process; • T cell differentiation in thymus; • female pregnancy; • cellular response to hormone stimulus; • positive regulation of activated T cell proliferation; • progesterone metabolic process; • receptor signaling pathway via JAK-STAT; • negative regulation of apoptotic process; • Peyer's patch development; • transcription, DNA-templated; • GO:0072468 signal transduction; • cellular response to growth factor stimulus; • natural killer cell differentiation; • response to interleukin-4; • sex differentiation; • valine metabolic process; • positive regulation of B cell differentiation; • T cell homeostasis; • creatine metabolic process; • cellular response to epidermal growth factor stimulus; • response to estradiol; • positive regulation of inflammatory response; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • mast cell migration; • positive regulation of mitotic cell cycle; • lipid storage; • development of secondary female sexual characteristics; • fatty acid metabolic process; • taurine metabolic process; • succinate metabolic process; • positive regulation of gamma-delta T cell differentiation; • positive regulation of lymphocyte differentiation; • regulation of multicellular organism growth; • citrate metabolic process; • positive regulation of cell population proliferation; • oxaloacetate metabolic process; • regulation of epithelial cell differentiation; • positive regulation of natural killer cell proliferation; • development of secondary male sexual characteristics; • positive regulation of multicellular organism growth; • GO:0009373 regulation of transcription, DNA-templated; • allantoin metabolic process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • luteinization; • isoleucine metabolic process; • negative regulation of erythrocyte differentiation; • lactation; • response to interleukin-15; • regulation of cell adhesion; • 2-oxoglutarate metabolic process; • response to interleukin-2; • growth hormone receptor signaling pathway via JAK-STAT; • positive regulation of erythrocyte differentiation; • peptidyl-tyrosine phosphorylation; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • defense response; • regulation of cell population proliferation; • response to peptide hormone;
	Sources:Amigo / QuickGO
Orthologau
	6777
	n/a
	ENSG00000173757
	n/a
	P51692
	n/a
	NM_012448
	n/a
	NP_036580
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT5B yw STAT5B a elwir hefyd yn Signal transducer and activator of transcription 5B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STAT5B.

STAT5

Llyfryddiaeth

"Interference of STAT 5b expression enhances the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. ". Oncol Rep. 2015. PMID 25997700.
"STAT5 is Activated by Epidermal Growth Factor and Induces Proliferation and Invasion in Trophoblastic Cells. ". Reprod Sci. 2015. PMID 25862676.
"Phospho-STAT5B Expression Is a Prognostic Marker for Merkel Cell Carcinoma. ". Anticancer Res. 2017. PMID 28476799.
"Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion. ". Oncol Rep. 2016. PMID 27035235.
"STAT5B mutations in heterozygous state have negative impact on height: another clue in human stature heritability.". Eur J Endocrinol. 2015. PMID 26034074.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] STAT5B - Cronfa NCBI

[1]

[2]