SUMO1

SUMO1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4WJQ, 1A5R, 1TGZ, 1WYW, 1Y8R, 1Z5S, 2ASQ, 2BF8, 2G4D, 2IO2, 2IY0, 2IY1, 2KQS, 2LAS, 2MW5, 2PE6, 2UYZ, 2VRR, 3KYC, 3KYD, 3RZW, 3UIP, 4WJN, 4WJO, 4WJP, 5AEK, 2N1V, 2N1A
Dynodwyr
Cyfenwau	SUMO1, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1, small ubiquitin-like modifier 1, small ubiquitin like modifier 1
Dynodwyr allanol	OMIM: 601912 HomoloGene: 2514 GeneCards: SUMO1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transcription factor binding; • potassium channel regulator activity; • GO:0001948, GO:0016582 protein binding; • protein tag; • ubiquitin protein ligase binding; • RNA binding; • transcription corepressor binding; • protein C-terminus binding; • SUMO transferase activity; • enzyme binding; • protein-macromolecule adaptor activity; • glucocorticoid receptor binding; • small protein activating enzyme binding; • ubiquitin-like protein ligase binding;
Cydrannau o'r gell	• cytoplasm; • PML body; • nuclear speck; • nuclear body; • nuclear membrane; • bilen; • voltage-gated potassium channel complex; • Cellbilen; • synapse; • nuclear pore; • nucleoplasm; • GO:0035328 heterochromatin; • XY body; • dendrite; • nucleolus; • fibrillar center; • cnewyllyn cell; • nuclear stress granule; • SUMO activating enzyme complex; • nuclear envelope; • cytosol;
Prosesau biolegol	• roof of mouth development; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • positive regulation of protein-containing complex assembly; • protein localization to nuclear pore; • protein stabilization; • negative regulation of action potential; • negative regulation of DNA-binding transcription factor activity; • regulation of protein localization; • regulation of cardiac muscle cell contraction; • global genome nucleotide-excision repair; • PML body organization; • regulation of interferon-gamma-mediated signaling pathway; • GO:0022415 viral process; • GO:0045996 negative regulation of transcription, DNA-templated; • double-strand break repair via nonhomologous end joining; • regulation of calcium ion transmembrane transport; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of delayed rectifier potassium channel activity; • positive regulation of ATPase-coupled calcium transmembrane transporter activity; • GO:0100026 DNA repair; • GO:1901227 negative regulation of transcription by RNA polymerase II; • cellular response to heat; • cellular response to cadmium ion; • protein sumoylation; • negative regulation of DNA binding;
	Sources:Amigo / QuickGO
Orthologau
	7341
	n/a
	ENSG00000116030
	n/a
	P63165
	n/a
	NM_003352; NM_001005781; NM_001005782
	n/a
NP_001005781; NP_001005782; NP_003343; NP_001358321; NP_001358322;
	NP_001358323
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SUMO1 yw SUMO1 a elwir hefyd yn Small ubiquitin-like modifier 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SUMO1.

DAP1
GMP1
PIC1
SMT3
UBL1
OFC10
SENP2
SMT3C
SMT3H3

Llyfryddiaeth

"SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells. ". Cell Physiol Biochem. 2017. PMID 28222440.
"A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide-Protein Conjugates. ". Bioconjug Chem. 2016. PMID 27195426.
"Roles for SUMO in pre-mRNA processing. ". Wiley Interdiscip Rev RNA. 2016. PMID 26563097.
"SUMO1 depletion prevents lipid droplet accumulation and HCV replication. ". Arch Virol. 2016. PMID 26449956.
"DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity.". Genet Mol Res. 2015. PMID 26400283.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SUMO1 - Cronfa NCBI

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[2]