SYT4

SYT4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UGK
Dynodwyr
Cyfenwau	SYT4, HsT1192, synaptotagmin 4
Dynodwyr allanol	OMIM: 600103 HomoloGene: 7559 GeneCards: SYT4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • clathrin binding; • phosphatidylserine binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • SNARE binding; • syntaxin-1 binding; • syntaxin binding; • syntaxin-3 binding; • protein homodimerization activity; • protein heterodimerization activity; • calcium-dependent phospholipid binding;
Cydrannau o'r gell	• integral component of membrane; • intracellular membrane-bounded organelle; • bilen; • synapse; • synaptic vesicle membrane; • cell junction; • perinuclear region of cytoplasm; • neuron projection; • dense core granule; • GO:0016023 cytoplasmic vesicle; • dendrite; • Golgi apparatus; • fesigl; • axon; • Cellbilen; • synaptic vesicle; • integral component of Golgi membrane; • integral component of synaptic vesicle membrane; • secretory granule membrane; • dense core granule membrane; • somatodendritic compartment; • soma; • neuron projection terminus; • exocytic vesicle; • astrocyte projection; • microvesicle; • glutamatergic synapse; • integral component of neuronal dense core vesicle membrane;
Prosesau biolegol	• cell differentiation; • brain development; • positive regulation of dendrite extension; • negative regulation of vesicle fusion; • GO:0010554 neurotransmitter secretion; • exocytosis; • vesicle fusion; • calcium ion-regulated exocytosis of neurotransmitter; • Cof; • positive regulation of glutamate secretion; • regulation of dopamine secretion; • regulation of endocytosis; • regulation of vesicle fusion; • negative regulation of catecholamine secretion; • positive regulation of calcium ion-dependent exocytosis; • negative regulation of neurotransmitter secretion; • negative regulation of short-term neuronal synaptic plasticity; • vesicle fusion with vesicle; • secretory granule maturation; • negative regulation of protein secretion; • negative regulation of retrograde trans-synaptic signaling by neuropeptide; • regulation of calcium ion-dependent exocytosis; • negative regulation of calcium ion-dependent exocytosis; • trans-synaptic signaling by BDNF, modulating synaptic transmission; • vesicle-mediated transport; • calcium-ion regulated exocytosis; • cellular response to calcium ion; • regulation of presynaptic dense core granule exocytosis; • negative regulation of dense core granule exocytosis; • positive regulation of dense core granule exocytosis; • negative regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	6860
	n/a
	ENSG00000132872
	n/a
	Q9H2B2
	n/a
	NM_020783
	n/a
	NP_065834
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SYT4 yw SYT4 a elwir hefyd yn Synaptotagmin-4 a Synaptotagmin 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q12.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SYT4.

HsT1192

Llyfryddiaeth

"Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. ". Neuron. 2011. PMID 21315262.
"Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown. ". BMC Neurosci. 2010. PMID 20735850.
"Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis. ". Neurochem Res. 2011. PMID 21153436.
"Upregulation and axonal transport of synaptotagmin-IV in the direct-pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine D1 receptor stimulation. ". Eur J Neurosci. 2016. PMID 26750488.
"The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.". J Biol Chem. 2000. PMID 10938284.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SYT4 - Cronfa NCBI

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[2]