TAB1

TAB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD
Dynodwyr
Cyfenwau	TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Dynodwyr allanol	OMIM: 602615 HomoloGene: 4461 GeneCards: TAB1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein serine/threonine phosphatase activity; • GO:0001948, GO:0016582 protein binding; • catalytic activity; • kinase activator activity; • GO:0010577 enzyme activator activity; • GO:0032403 protein-containing complex binding; • mitogen-activated protein kinase p38 binding; • protein kinase activator activity;
Cydrannau o'r gell	• endosome membrane; • cytosol; • nuclear speck; • GO:0009327 protein-containing complex; • cnewyllyn cell;
Prosesau biolegol	• cardiac septum development; • lung development; • GO:0016576 protein dephosphorylation; • heart morphogenesis; • stimulatory C-type lectin receptor signaling pathway; • in utero embryonic development; • MyD88-dependent toll-like receptor signaling pathway; • coronary vasculature development; • Fc-epsilon receptor signaling pathway; • JNK cascade; • aorta development; • positive regulation of NF-kappaB transcription factor activity; • I-kappaB kinase/NF-kappaB signaling; • transforming growth factor beta receptor signaling pathway; • nucleotide-binding oligomerization domain containing signaling pathway; • positive regulation of MAP kinase activity; • protein deubiquitination; • interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	10454
	n/a
	ENSG00000100324
	n/a
	Q15750
	n/a
	NM_153497; NM_006116
	n/a
	NP_006107; NP_705717
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAB1 yw TAB1 a elwir hefyd yn TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAB1.

3'-Tab1
MAP3K7IP1

Llyfryddiaeth

"TAK1-binding protein 1 is a pseudophosphatase. ". Biochem J. 2006. PMID 16879102.
"Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. ". Int J Clin Exp Pathol. 2015. PMID 26884850.
"TAB1: a target of triptolide in macrophages. ". Chem Biol. 2014. PMID 24462677.
"The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. ". Am J Pathol. 2012. PMID 22525462.
"Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.". PLoS One. 2011. PMID 22216226.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TAB1 - Cronfa NCBI

[1]

[2]