TCF7L2 |
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Dynodwyr |
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Cyfenwau | TCF7L2, TCF-4, TCF4, transcription factor 7 like 2 |
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Dynodwyr allanol | OMIM: 602228 HomoloGene: 7564 GeneCards: TCF7L2 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • sequence-specific DNA binding • DNA binding • beta-catenin binding • gamma-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • armadillo repeat domain binding • protein kinase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding
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Cydrannau o'r gell | • beta-catenin-TCF7L2 complex • PML body • nucleoplasm • protein-DNA complex • cnewyllyn cell • transcription regulator complex
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Prosesau biolegol | • positive regulation of heparan sulfate proteoglycan biosynthetic process • positive regulation of protein kinase B signaling • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to glucose • Wnt signaling pathway • regulation of smooth muscle cell proliferation • negative regulation of DNA-binding transcription factor activity • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition • transcription, DNA-templated • positive regulation of protein export from nucleus • maintenance of DNA repeat elements • blood vessel development • myoblast fate commitment • canonical Wnt signaling pathway • pancreas development • positive regulation of protein binding • regulation of hormone metabolic process • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • beta-catenin-TCF complex assembly • Wnt signaling pathway, calcium modulating pathway • positive regulation of insulin secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of type B pancreatic cell apoptotic process • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of epithelial cell proliferation
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn TCF7L2 yw TCF7L2 a elwir hefyd yn TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14 , T-cell factor-4 variant L a Transcription factor 7 like 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.2-q25.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TCF7L2.
- "Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol. ". PLoS One. 2017. PMID 29182660.
- "Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma. ". Cell Mol Biol Lett. 2016. PMID 28536608.
- "Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. ". J Health Popul Nutr. 2017. PMID 28420445.
- "A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women. ". PLoS One. 2017. PMID 28253288.
- "Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146.". Metabolism. 2017. PMID 28183453.