TEAD4

TEAD4
Dynodwyr
Cyfenwau	TEAD4, EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, TEA domain transcription factor 4
Dynodwyr allanol	OMIM: 601714 HomoloGene: 74463 GeneCards: TEAD4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948, GO:0016582 protein binding; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• nucleoplasm; • transcription regulator complex; • cnewyllyn cell;
Prosesau biolegol	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • skeletal system development; • muscle organ development; • transcription initiation from RNA polymerase II promoter; • GO:0009373 regulation of transcription, DNA-templated; • hippo signaling; • transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • embryonic organ development;
	Sources:Amigo / QuickGO
Orthologau
	7004
	n/a
	ENSG00000197905
	n/a
	Q15561
	n/a
	NM_201443; NM_003213; NM_201441
	n/a
	NP_003204; NP_958849; NP_958851
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TEAD4 yw TEAD4 a elwir hefyd yn TEA domain transcription factor 4 a Transcriptional enhancer factor TEF-3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TEAD4.

TEF3
RTEF1
TEF-3
EFTR-2
TEFR-1
TCF13L1
hRTEF-1B

Llyfryddiaeth

"Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. ". Oncogene. 2016. PMID 26387538.
"RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. ". Exp Biol Med (Maywood). 2015. PMID 26041389.
"DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. ". Oncogene. 2017. PMID 28368398.
"Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. ". Pediatr Blood Cancer. 2017. PMID 27966820.
"Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer.". Oncotarget. 2016. PMID 26885617.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TEAD4 - Cronfa NCBI

[1]

[2]