TH

TH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2XSN, 4J6S
Dynodwyr
Cyfenwau	TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase
Dynodwyr allanol	OMIM: 191290 HomoloGene: 307 GeneCards: TH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• tetrahydrobiopterin binding; • tyrosine 3-monooxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; • ferrous iron binding; • oxygen binding; • metal ion binding; • dopamine binding; • enzyme binding; • oxidoreductase activity; • iron ion binding; • ferric iron binding; • GO:0001948, GO:0016582 protein binding; • amino acid binding; • monooxygenase activity; • protein domain specific binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • mitocondria; • neuron projection; • cytoplasmic side of plasma membrane; • cnewyllyn cell; • synaptic vesicle; • melanosome membrane; • terminal bouton; • perikaryon; • axon; • soma; • smooth endoplasmic reticulum; • dendrite; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle;
Prosesau biolegol	• regulation of heart contraction; • response to salt stress; • response to steroid hormone; • response to amphetamine; • isoquinoline alkaloid metabolic process; • response to zinc ion; • terpene metabolic process; • learning; • epinephrine biosynthetic process; • synaptic transmission, dopaminergic; • circadian sleep/wake cycle; • multicellular organism aging; • animal organ morphogenesis; • response to growth factor; • response to ethanol; • cellular response to glucose stimulus; • phthalate metabolic process; • locomotory behavior; • response to light stimulus; • anatomical structure morphogenesis; • response to nicotine; • response to metal ion; • Cof; • heart development; • response to nutrient levels; • embryonic camera-type eye morphogenesis; • social behavior; • cellular response to manganese ion; • response to ether; • sphingolipid metabolic process; • response to immobilization stress; • norepinephrine biosynthetic process; • gwybyddiaeth; • dopamine biosynthetic process; • response to corticosterone; • cellular response to nicotine; • cellular response to alkaloid; • mating behavior; • response to electrical stimulus; • response to isolation stress; • glycoside metabolic process; • aromatic amino acid family metabolic process; • response to lipopolysaccharide; • cerebral cortex development; • response to pyrethroid; • pigmentation; • phytoalexin metabolic process; • response to herbicide; • golwg; • response to estradiol; • response to hypoxia; • GO:1904578 response to organic cyclic compound; • eating behavior; • cellular response to growth factor stimulus; • heart morphogenesis; • response to water deprivation; • catecholamine biosynthetic process; • neurotransmitter biosynthetic process; • response to peptide hormone; • clyw; • response to activity; • fatty acid metabolic process; • eye photoreceptor cell development; • response to insecticide; • dopamine biosynthetic process from tyrosine; • aminergic neurotransmitter loading into synaptic vesicle;
	Sources:Amigo / QuickGO
Orthologau
	7054
	n/a
	ENSG00000180176
	n/a
	P07101; P78428
	n/a
	NM_000360; NM_199292; NM_199293
	n/a
	NP_000351; NP_954986; NP_954987; NP_954986.2; NP_954987.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TH yw TH a elwir hefyd yn Tyrosine hydroxylase a Tyrosine 3-monooxygenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TH.

TYH
DYT14
DYT5b

Llyfryddiaeth

"A new knock-in mouse model of l-DOPA-responsive dystonia. ". Brain. 2015. PMID 26220941.
"The hTH-GFP reporter rat model for the study of Parkinson's disease. ". PLoS One. 2014. PMID 25462571.
"The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease. ". Parkinsonism Relat Disord. 2016. PMID 26732803.
"The Effect of Perinatal Hypoxic/Ischemic Injury on Tyrosine Hydroxylase Expression in the Locus Coeruleus of the Human Neonate. ". Dev Neurosci. 2016. PMID 26647061.
"Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.". Brain. 2015. PMID 26276013.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TH - Cronfa NCBI

[1]

[2]