THRB

THRB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1
Dynodwyr
Cyfenwau	THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta
Dynodwyr allanol	OMIM: 190160 HomoloGene: 36025 GeneCards: THRB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • chromatin DNA binding; • thyroid hormone binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000975 transcription cis-regulatory region binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • nuclear body; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • regulation of heart contraction; • female courtship behavior; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:1901227 negative regulation of transcription by RNA polymerase II; • clyw; • type I pneumocyte differentiation; • negative regulation of female receptivity; • animal organ morphogenesis; • transcription initiation from RNA polymerase II promoter; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • steroid hormone mediated signaling pathway; • intracellular receptor signaling pathway; • transcription, DNA-templated; • negative regulation of eye photoreceptor cell development; • retinal cone cell development; • retinal cone cell apoptotic process; • multicellular organism development; • hormone-mediated signaling pathway; • cell differentiation; • thyroid gland development; • response to lipid; • thyroid hormone mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7068
	n/a
	ENSG00000151090
	n/a
	P10828
	n/a
NM_000461; NM_001128176; NM_001128177; NM_001252634; NM_001354708;
	NM_001354709; NM_001354710; NM_001354711; NM_001354712; NM_001354713; NM_001354714; NM_001354715; NM_001374822; NM_001374823; NM_001374824; NM_001374825; NM_001374826; NM_001374827
	n/a
NP_000452; NP_001121648; NP_001121649; NP_001239563; NP_001341637;
	NP_001341638; NP_001341639; NP_001341640; NP_001341641; NP_001341642; NP_001341643; NP_001341644; NP_001361751; NP_001361752; NP_001361753; NP_001361754; NP_001361755; NP_001361756
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn THRB yw THRB a elwir hefyd yn Thyroid hormone receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p24.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THRB.

GRTH
PRTH
THR1
ERBA2
NR1A2
THRB1
THRB2
C-ERBA-2
C-ERBA-BETA

Llyfryddiaeth

"Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β. ". Mol Carcinog. 2017. PMID 27254276.
"Molecular characterization of human thyroid hormone receptor β isoform 4. ". Endocr Res. 2016. PMID 26513165.
"A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor. ". Mol Cell Endocrinol. 2017. PMID 28257829.
"A new TRβ mutation in resistance to thyroid hormone syndrome. ". Hormones (Athens). 2016. PMID 28222413.
"Thyroid hormone resistance syndrome caused by heterozygous A317T mutation in thyroid hormone receptor β gene: Report of one Chinese pedigree and review of the literature.". Medicine (Baltimore). 2016. PMID 27537566.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] THRB - Cronfa NCBI

[1]

[2]