TLE4

TLE4
Dynodwyr
Cyfenwau	TLE4, BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4, transducin like enhancer of split 4, TLE family member 4, transcriptional corepressor, E(spl)
Dynodwyr allanol	OMIM: 605132 HomoloGene: 38259 GeneCards: TLE4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • GO:0001106 transcription corepressor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • molecular function;
Cydrannau o'r gell	• cnewyllyn cell; • nucleoplasm; • transcription regulator complex; • beta-catenin-TCF complex;
Prosesau biolegol	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • Wnt signaling pathway; • transcription, DNA-templated; • beta-catenin-TCF complex assembly; • cellular response to leukemia inhibitory factor; • GO:0022610 proses fiolegol; • negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7091
	n/a
	ENSG00000106829
	n/a
	Q04727
	n/a
NM_001282748; NM_001282749; NM_001282753; NM_001282760; NM_007005;
	NM_001351541; NM_001351542; NM_001351543; NM_001351546; NM_001351547; NM_001351550; NM_001351552; NM_001351558; NM_001351560; NM_001351562; NM_001351563; NM_001351564; NM_001351556
	n/a
NP_001269677; NP_001269678; NP_001269682; NP_001269689; NP_008936;
	NP_001338470; NP_001338471; NP_001338472; NP_001338475; NP_001338476; NP_001338479; NP_001338481; NP_001338487; NP_001338489; NP_001338491; NP_001338492; NP_001338493; NP_001338485
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLE4 yw TLE4 a elwir hefyd yn Transducin like enhancer of split 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLE4.

ESG
BCE1
ESG4
GRG4
BCE-1
Grg-4
E(spI)

Llyfryddiaeth

"Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. ". PLoS Genet. 2009. PMID 19714205.
"A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. ". Immunology. 2002. PMID 12153506.
"TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia. ". Leuk Res. 2016. PMID 27486062.
"TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway. ". Oncotarget. 2016. PMID 26701208.
"The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.". Biochem Biophys Res Commun. 2013. PMID 24099773.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TLE4 - Cronfa NCBI

[1]

[2]