TNFSF18

TNFSF18
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2Q1M, 2R30, 2R32, 3B93, 3B94
Dynodwyr
Cyfenwau	TNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
Dynodwyr allanol	OMIM: 603898 HomoloGene: 3732 GeneCards: TNFSF18
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • signaling receptor binding; • GO:0001948, GO:0016582 protein binding; • tumor necrosis factor receptor superfamily binding; • identical protein binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • extracellular space; • cell surface;
Prosesau biolegol	• adaptive immune response; • positive regulation of leukocyte migration; • immune system process; • cell-cell signaling; • negative regulation of apoptotic process; • GO:0072468 signal transduction; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • T cell proliferation involved in immune response; • tumor necrosis factor-mediated signaling pathway; • regulation of T cell proliferation; • positive regulation of cell adhesion; • positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologau
	8995
	n/a
	ENSG00000120337
	n/a
	Q9UNG2
	n/a
	NM_005092
	n/a
	NP_005083
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFSF18 yw TNFSF18 a elwir hefyd yn TNF superfamily member 18 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFSF18.

TL6
AITRL
GITRL
TNLG2A
hGITRL

Llyfryddiaeth

"Correlation of circulating glucocorticoid-induced TNFR-related protein ligand levels with disease activity in patients with systemic lupus erythematosus. ". Clin Dev Immunol. 2012. PMID 23251213.
"GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity. ". J Immunol. 2012. PMID 22649191.
"GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis. ". Clin Rheumatol. 2016. PMID 27098050.
"GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis. ". Oncotarget. 2016. PMID 26657118.
"Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.". Int J Mol Sci. 2014. PMID 25429429.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TNFSF18 - Cronfa NCBI

[1]

[2]