TNK2

TNK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CF4, 1U46, 1U4D, 1U54, 3EQP, 3EQR, 4EWH, 4HZR, 4HZS, 4ID7
Dynodwyr
Cyfenwau	TNK2, ACK, ACK-1, ACK1, p21cdc42Hs, tyrosine kinase non receptor 2
Dynodwyr allanol	OMIM: 606994 HomoloGene: 4224 GeneCards: TNK2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • epidermal growth factor receptor binding; • GTPase inhibitor activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • WW domain binding; • protein tyrosine kinase activity; • ATP binding; • ubiquitin protein ligase binding; • non-membrane spanning protein tyrosine kinase activity; • protein serine/threonine/tyrosine kinase activity;
Cydrannau o'r gell	• endosome; • bilen; • extrinsic component of cytoplasmic side of plasma membrane; • adherens junction; • Cellbilen; • cell junction; • Grb2-EGFR complex; • clathrin-coated pit; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • cnewyllyn cell; • clathrin-coated vesicle; • cytoplasm; • perinuclear region of cytoplasm; • cytoophidium;
Prosesau biolegol	• cell differentiation; • endocytosis; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • small GTPase mediated signal transduction; • protein phosphorylation; • cell surface receptor signaling pathway; • regulation of cell population proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • peptidyl-tyrosine autophosphorylation; • regulation of clathrin-dependent endocytosis; • innate immune response; • cell migration; • GO:0034259 negative regulation of GTPase activity; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	10188
	n/a
	ENSG00000061938
	n/a
	Q07912
	n/a
NM_001010938; NM_001308046; NM_005781; NM_001382271; NM_001382272;
	NM_001382273; NM_001382274; NM_001382275
	n/a
	NP_001010938; NP_001294975; NP_005772
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNK2 yw TNK2 a elwir hefyd yn Activated CDC42 kinase 1 a Tyrosine kinase non receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q29.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNK2.

ACK
ACK1
ACK-1
p21cdc42Hs

Llyfryddiaeth

"Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation. ". Oncotarget. 2017. PMID 26498357.
"ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling. ". Int J Oncol. 2015. PMID 25738261.
"Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms. ". Med Sci Monit. 2016. PMID 27926694.
"Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. ". Cancer Res. 2016. PMID 26677978.
"Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.". Oncotarget. 2015. PMID 26536663.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TNK2 - Cronfa NCBI

[1]

[2]