TOLLIP

TOLLIP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WGL, 2N31
Dynodwyr
Cyfenwau	TOLLIP, IL-1RAcPIP, toll interacting protein
Dynodwyr allanol	OMIM: 606277 HomoloGene: 10375 GeneCards: TOLLIP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signal transducer activity; • Toll-like receptor binding; • SUMO binding; • kinase binding; • GO:0001948, GO:0016582 protein binding; • interleukin-1, type I receptor binding; • ubiquitin protein ligase binding; • ubiquitin conjugating enzyme binding; • ubiquitin binding;
Cydrannau o'r gell	• interleukin-18 receptor complex; • cytosol; • nuclear body; • perinuclear region of cytoplasm; • interleukin-1 receptor complex; • extracellular exosome; • extracellular region; • cytoplasm; • azurophil granule lumen; • specific granule lumen;
Prosesau biolegol	• GO:0007243 intracellular signal transduction; • epithelial cell differentiation; • phosphorylation; • immune system process; • leukocyte activation; • cell-cell signaling; • positive regulation of protein sumoylation; • autophagy; • protein localization to endosome; • innate immune response; • inflammatory response; • GO:0072468 signal transduction; • ubiquitin-dependent protein catabolic process; • neutrophil degranulation; • interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	54472
	n/a
	ENSG00000078902
	n/a
	Q9H0E2; Q6FIE9
	n/a
	NM_019009; NM_001318512; NM_001318514; NM_001318515; NM_001318516
	n/a
NP_001305441; NP_001305443; NP_001305444; NP_001305445; NP_061882;
	NP_061882.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOLLIP yw TOLLIP a elwir hefyd yn Toll interacting protein, isoform CRA_b a Toll interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TOLLIP.

IL-1RAcPIP

Llyfryddiaeth

"Toll-interacting protein inhibits HIV-1 infection and regulates viral latency. ". Biochem Biophys Res Commun. 2016. PMID 27181351.
"Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. ". Am J Transplant. 2016. PMID 26663441.
"A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis. ". Am J Respir Crit Care Med. 2017. PMID 28463648.
"Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. ". Clin Exp Allergy. 2016. PMID 27513438.
"Pharmacogenetics and interstitial lung disease.". Curr Opin Pulm Med. 2016. PMID 27253772.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TOLLIP - Cronfa NCBI

[1]

[2]