TP53BP2

TP53BP2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1YCS, 2UWQ, 4A63, 4IRV
Dynodwyr
Cyfenwau	TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Dynodwyr allanol	OMIM: 602143 HomoloGene: 3959 GeneCards: TP53BP2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • identical protein binding; • p53 binding; • SH3 domain binding; • NF-kappaB binding;
Cydrannau o'r gell	• perinuclear region of cytoplasm; • cnewyllyn cell; • cytoplasm; • mitocondria; • nucleoplasm; • cytosol; • cell junction;
Prosesau biolegol	• cell cycle; • negative regulation of cell cycle; • positive regulation of execution phase of apoptosis; • GO:0072468 signal transduction; • intrinsic apoptotic signaling pathway by p53 class mediator; • GO:0097285 apoptotic process; • positive regulation of neuron death; • regulation of signal transduction by p53 class mediator; • regulation of apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7159
	n/a
	ENSG00000143514
	n/a
	Q13625
	n/a
	NM_001031685; NM_005426
	n/a
	NP_001026855; NP_005417
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP53BP2 yw TP53BP2 a elwir hefyd yn Tumor protein p53 binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q41.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP53BP2.

BBP
53BP2
ASPP2
P53BP2
PPP1R13A

Llyfryddiaeth

"Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2. ". Proc Natl Acad Sci U S A. 2014. PMID 24474782.
"Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function. ". PLoS One. 2013. PMID 24312625.
"miR-548d-3p/TP53BP2 axis regulates the proliferation and apoptosis of breast cancer cells. ". Cancer Med. 2016. PMID 26663100.
"Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation. ". Mol Cancer. 2015. PMID 26438046.
"An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA.". Biochemistry. 2015. PMID 25963096.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TP53BP2 - Cronfa NCBI

[1]

[2]