TPM1

TPM1
Dynodwyr
Cyfenwau	TPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 1
Dynodwyr allanol	OMIM: 191010 HomoloGene: 121635 GeneCards: TPM1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytoskeletal protein binding; • structural constituent of cytoskeleton; • GO:0001948, GO:0016582 protein binding; • actin binding; • structural constituent of muscle; • identical protein binding; • protein homodimerization activity; • protein heterodimerization activity; • actin filament binding;
Cydrannau o'r gell	• cytoplasm; • muscle thin filament tropomyosin; • sarcomere; • stress fiber; • ruffle membrane; • bleb; • Cytosgerbwd; • cytosol; • Microffilament; • actin cytoskeleton; • Myoffibril; • filamentous actin;
Prosesau biolegol	• regulation of muscle contraction; • muscle contraction; • regulation of heart contraction; • positive regulation of ATP-dependent activity; • negative regulation of vascular associated smooth muscle cell migration; • negative regulation of vascular associated smooth muscle cell proliferation; • ruffle organization; • wound healing; • GO:0072353 cellular response to reactive oxygen species; • negative regulation of cell migration; • cytoskeleton organization; • regulation of cell shape; • muscle filament sliding; • sarcomere organization; • positive regulation of stress fiber assembly; • positive regulation of cell adhesion; • actin filament organization; • in utero embryonic development; • positive regulation of heart rate by epinephrine; • ventricular cardiac muscle tissue morphogenesis; • cardiac muscle contraction;
	Sources:Amigo / QuickGO
Orthologau
	7168
	n/a
	ENSG00000140416
	n/a
	P09493
	n/a
NM_000366; NM_001018004; NM_001018005; NM_001018006; NM_001018007;
	NM_001018008; NM_001018020; NM_001301244; NM_001301289; NM_001330344; NM_001330346; NM_001330351; NM_001365776; NM_001365777; NM_001365778; NM_001365779; NM_001365780; NM_001365781; NM_001365782
	n/a
NP_000357; NP_001018004; NP_001018005; NP_001018006; NP_001018007;
	NP_001018008; NP_001018020; NP_001288173; NP_001288218; NP_001317273; NP_001317275; NP_001317280; NP_001352705; NP_001352706; NP_001352707; NP_001352708; NP_001352709; NP_001352710; NP_001352711; NP_001018006.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPM1 yw TPM1 a elwir hefyd yn Tropomyosin alpha-1 chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPM1.

CMH3
TMSA
CMD1Y
LVNC9
C15orf13
HEL-S-265
HTM-alpha

Llyfryddiaeth

"Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle. ". Bull Exp Biol Med. 2016. PMID 27878731.
"The impact of tropomyosins on actin filament assembly is isoform specific. ". Bioarchitecture. 2016. PMID 27420374.
"The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics. ". Arch Biochem Biophys. 2017. PMID 28732641.
"Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma. ". PLoS One. 2017. PMID 28182650.
"Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.". Biochemistry. 2017. PMID 27983818.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TPM1 - Cronfa NCBI

[1]

[2]