TPMT

TPMT
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2BZG, 2H11
Dynodwyr
Cyfenwau	TPMT, entrez:7172, TPMTD, thiopurine S-methyltransferase
Dynodwyr allanol	OMIM: 187680 HomoloGene: 313 GeneCards: TPMT
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• S-adenosylmethionine-dependent methyltransferase activity; • transferase activity; • GO:0102674, GO:0102675 methyltransferase activity; • thiopurine S-methyltransferase activity; • S-adenosyl-L-methionine binding;
Cydrannau o'r gell	• cytosol; • cytoplasm;
Prosesau biolegol	• nucleobase-containing compound metabolic process; • methylation;
	Sources:Amigo / QuickGO
Orthologau
	7172
	n/a
	ENSG00000137364
	n/a
	P51580
	n/a
	NM_000367; NM_001346817; NM_001346818
	n/a
	NP_000358; NP_001333746; NP_001333747
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPMT yw TPMT a elwir hefyd yn Thiopurine S-methyltransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPMT.

TPMTD

Llyfryddiaeth

"Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods. ". Cardiovasc Hematol Agents Med Chem. 2017. PMID 28552060.
"Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients. ". Arch Med Res. 2016. PMID 28476189.
"Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies. ". Clin Pharmacol Ther. 2017. PMID 27770449.
"Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders. ". Dig Liver Dis. 2016. PMID 27665263.
"Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.". Clin Pharmacol Ther. 2017. PMID 27564568.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TPMT - Cronfa NCBI

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[2]