TRAF6

TRAF6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M
Dynodwyr
Cyfenwau	TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
Dynodwyr allanol	OMIM: 602355 HomoloGene: 3395 GeneCards: TRAF6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • histone deacetylase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • mitogen-activated protein kinase kinase kinase binding • zinc ion binding • GO:0001948, GO:0016582 protein binding • thioesterase binding • ubiquitin conjugating enzyme binding • protein kinase binding • protein kinase B binding • GO:0050372 ubiquitin-protein transferase activity • identical protein binding • ubiquitin protein ligase binding • transferase activity • tumor necrosis factor receptor binding Cydrannau o'r gell • cytoplasm • cytosol • lipid droplet • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • cnewyllyn cell • Cellbilen • cell cortex • endosome membrane • CD40 receptor complex • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of transcription regulatory region DNA binding • response to interleukin-1 • toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • odontogenesis of dentin-containing tooth • animal organ morphogenesis • T-helper 1 type immune response • toll-like receptor 9 signaling pathway • regulation of apoptotic process • ossification • cytokine-mediated signaling pathway • osteoclast differentiation • positive regulation of osteoclast differentiation • stimulatory C-type lectin receptor signaling pathway • activation of NF-kappaB-inducing kinase activity • bone resorption • JNK cascade • membrane protein intracellular domain proteolysis • protein ubiquitination • positive regulation of T cell proliferation • I-kappaB kinase/NF-kappaB signaling • protein autoubiquitination • immune system process • positive regulation of JUN kinase activity • positive regulation of DNA-binding transcription factor activity • protein polyubiquitination • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • positive regulation of T cell cytokine production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • GO:0045996 negative regulation of transcription, DNA-templated • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein ubiquitination • positive regulation of smooth muscle cell proliferation • antigen processing and presentation of exogenous peptide antigen via MHC class II • cell development • protein K63-linked ubiquitination • myeloid dendritic cell differentiation • MyD88-dependent toll-like receptor signaling pathway • neural tube closure • bone remodeling • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to lipopolysaccharide • T cell receptor signaling pathway • activation of protein kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • cellular response to DNA damage stimulus • protein deubiquitination • regulation of I-kappaB kinase/NF-kappaB signaling • interleukin-1-mediated signaling pathway • cellular response to cytokine stimulus • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7189	n/a
Ensembl	ENSG00000175104	n/a
UniProt	Q9Y4K3	n/a
RefSeq (mRNA)	NM_145803 NM_004620	n/a
RefSeq (protein)	NP_004611 NP_665802	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRAF6 yw TRAF6 a elwir hefyd yn TNF receptor associated factor 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRAF6.

• RNF85
• MGC:3310

Llyfryddiaeth

• "Role of the MAPKs/TGF-β1/TRAF6 signaling pathway in postoperative atrial fibrillation. ". PLoS One. 2017. PMID 28323847.
• "High TRAF6 Expression Is Associated With Esophageal Carcinoma Recurrence and Prompts Cancer Cell Invasion. ". Oncol Res. 2017. PMID 27697099.
• "Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6. ". J Virol. 2016. PMID 27681126.
• "siRNA-induced TRAF6 knockdown promotes the apoptosis and inhibits the invasion of human lung cancer SPC-A1 cells. ". Oncol Rep. 2016. PMID 26847475.
• "TRAF6 promotes the invasion and metastasis and predicts a poor prognosis in gastric cancer.". Pathol Res Pract. 2016. PMID 26627263.

Cyfeiriadau

1. "Human PubMed Reference:".
2. TRAF6 - Cronfa NCBI