TRIM9

TRIM9
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2DB8
Dynodwyr
Cyfenwau	TRIM9, RNF91, SPRING, tripartite motif containing 9
Dynodwyr allanol	OMIM: 606555 HomoloGene: 9045 GeneCards: TRIM9
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • zinc ion binding; • GO:0001948, GO:0016582 protein binding; • protein homodimerization activity; • transferase activity; • protein domain specific binding; • GO:0050372 ubiquitin-protein transferase activity; • SNARE binding;
Cydrannau o'r gell	• cytoplasm; • GO:0016023 cytoplasmic vesicle; • cell junction; • dendrite; • cell projection; • synapse; • Cytosgerbwd; • synaptic vesicle; • intracellular anatomical structure; • cytosol; • presynaptic cytosol;
Prosesau biolegol	• negative regulation of calcium ion-dependent exocytosis; • protein ubiquitination; • negative regulation of SNARE complex assembly; • synaptic vesicle exocytosis; • proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	114088
	n/a
	ENSG00000100505
	n/a
	Q9C026
	n/a
	NM_015163; NM_052978
	n/a
	NP_055978; NP_443210
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRIM9 yw TRIM9 a elwir hefyd yn Tripartite motif containing 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRIM9.

RNF91
SPRING

Llyfryddiaeth

"Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. ". Nat Commun. 2014. PMID 25190485.
"The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance. ". Dev Cell. 2015. PMID 26702829.
"TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1. ". Cell Res. 2016. PMID 26915459.
"TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies. ". Neurobiol Dis. 2010. PMID 20085810.
"TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.". Mol Biol Cell. 2017. PMID 28701345.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TRIM9 - Cronfa NCBI

[1]

[2]