TSG101

TSG101
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KPP, 1KPQ, 1M4P, 1M4Q, 1S1Q, 2F0R, 3IV1, 3OBQ, 3OBS, 3OBU, 3OBX, 3P9G, 3P9H, 4EJE, 4YC1, 4ZNY
Dynodwyr
Cyfenwau	TSG101, TSG10, VPS23, tumor susceptibility 101
Dynodwyr allanol	OMIM: 601387 HomoloGene: 4584 GeneCards: TSG101
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein homodimerization activity; • GO:0001106 transcription corepressor activity; • calcium-dependent protein binding; • ubiquitin binding; • GO:0001948, GO:0016582 protein binding; • nuclear receptor coactivator activity; • virion binding; • ubiquitin protein ligase binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• cytoplasm; • multivesicular body; • endosome; • late endosome; • bilen; • late endosome membrane; • Cellbilen; • early endosome; • nucleolus; • endosome membrane; • extracellular exosome; • ESCRT I complex; • cnewyllyn cell; • cytosol; • host cell; • microtubule organizing center; • Cytosgerbwd; • early endosome membrane; • Flemming body;
Prosesau biolegol	• GO:0046795 intracellular transport of virus; • cell differentiation; • positive regulation of ubiquitin-dependent endocytosis; • regulation of extracellular exosome assembly; • viral budding via host ESCRT complex; • GO:0019067 viral life cycle; • endosome to lysosome transport; • multivesicular body assembly; • protein monoubiquitination; • viral budding; • keratinocyte differentiation; • Cellraniad; • endosomal transport; • GO:0000046 autophagosome maturation; • regulation of cell growth; • protein transport; • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; • regulation of MAP kinase activity; • positive regulation of exosomal secretion; • cell cycle; • regulation of growth; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of cell population proliferation; • GO:0022415 viral process; • exosomal secretion; • macroautophagy; • negative regulation of epidermal growth factor receptor signaling pathway; • negative regulation of epidermal growth factor-activated receptor activity; • GO:0015915 transport; • extracellular transport; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologau
	7251
	n/a
	ENSG00000074319
	n/a
	Q99816
	n/a
	NM_006292
	n/a
	NP_006283
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TSG101 yw TSG101 a elwir hefyd yn Tumor susceptibility gene 101 protein a Tumor susceptibility 101 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TSG101.

TSG10
VPS23

Llyfryddiaeth

"Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells. ". PLoS Pathog. 2014. PMID 25330247.
"Human papillomavirus infection requires the TSG101 component of the ESCRT machinery. ". Virology. 2014. PMID 25010273.
"TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death. ". Med Sci Monit. 2015. PMID 26537625.
"Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line. ". Genet Mol Res. 2015. PMID 26400331.
"Functional Interaction Between the ESCRT-I Component TSG101 and the HSV-1 Tegument Ubiquitin Specific Protease.". J Cell Physiol. 2015. PMID 25510868.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TSG101 - Cronfa NCBI

[1]

[2]