TTK

TTK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8
Dynodwyr
Cyfenwau	TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase
Dynodwyr allanol	OMIM: 604092 HomoloGene: 2489 GeneCards: TTK
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• kinase activity; • transferase activity; • protein serine/threonine/tyrosine kinase activity; • protein serine/threonine kinase activity; • protein tyrosine kinase activity; • nucleotide binding; • protein kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • protein homodimerization activity; • kinetochore binding;
Cydrannau o'r gell	• spindle; • bilen; • cytoplasm; • kinetochore; • cnewyllyn cell;
Prosesau biolegol	• chromosome separation; • GO:0043148 mitotic spindle organization; • positive regulation of pathway-restricted SMAD protein phosphorylation; • GO:0043146 spindle organization; • mitotic spindle assembly checkpoint signaling; • positive regulation of cell population proliferation; • protein phosphorylation; • phosphorylation; • mitotic cell cycle checkpoint signaling; • peptidyl-tyrosine phosphorylation; • female meiosis chromosome segregation; • GO:0035404 peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • meiotic spindle assembly checkpoint signaling; • protein localization to kinetochore; • protein localization to chromosome; • protein autophosphorylation; • protein localization to meiotic spindle midzone; • chromosome segregation;
	Sources:Amigo / QuickGO
Orthologau
	7272
	n/a
	ENSG00000112742
	n/a
	P33981
	n/a
	NM_001166691; NM_003318
	n/a
	NP_001160163; NP_003309
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TTK yw TTK a elwir hefyd yn TTK protein kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TTK.

ESK
PYT
CT96
MPH1
MPS1
MPS1L1

Llyfryddiaeth

"Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. ". PLoS One. 2017. PMID 28380042.
"Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. ". Cell Death Dis. 2016. PMID 27383047.
"Whole-Exome Sequencing Identifies the 6q12-q16 Linkage Region and a Candidate Gene, TTK, for Pulmonary Nontuberculous Mycobacterial Disease. ". Am J Respir Crit Care Med. 2017. PMID 28777004.
"Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma. ". Oncogene. 2017. PMID 28759042.
"Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.". J Biol Chem. 2017. PMID 28726638.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TTK - Cronfa NCBI

[1]

[2]