TYROBP

TYROBP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2L34, 2L35, 4WO1, 4WOL
Dynodwyr
Cyfenwau	TYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP
Dynodwyr allanol	OMIM: 604142 HomoloGene: 7986 GeneCards: TYROBP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signaling receptor binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • metal ion binding;
Cydrannau o'r gell	• integral component of membrane; • cell surface; • Cellbilen; • integral component of plasma membrane; • bilen; • secretory granule membrane;
Prosesau biolegol	• integrin-mediated signaling pathway; • macrophage activation involved in immune response; • cellular defense response; • neutrophil activation involved in immune response; • GO:0007243 intracellular signal transduction; • innate immune response; • regulation of osteoclast development; • GO:0072468 signal transduction; • regulation of immune response; • neutrophil degranulation; • osteoclast differentiation; • myeloid leukocyte activation; • positive regulation of natural killer cell activation; • positive regulation of macrophage fusion; • protein stabilization; • positive regulation of microglial cell mediated cytotoxicity; • positive regulation of protein localization to cell surface; • positive regulation of osteoclast development; • microglial cell activation involved in immune response; • GO:1901313 positive regulation of gene expression; • actin cytoskeleton organization; • negative regulation of B cell proliferation; • forebrain development; • negative regulation of transforming growth factor beta1 production; • positive regulation of superoxide anion generation; • response to axon injury; • apoptotic signaling pathway; • positive regulation of hippocampal neuron apoptotic process; • negative regulation of long-term synaptic potentiation; • positive regulation of neuron death; • positive regulation of receptor localization to synapse; • apoptotic cell clearance; • immune system process;
	Sources:Amigo / QuickGO
Orthologau
	7305
	n/a
	ENSG00000011600
	n/a
	O43914
	n/a
	NM_001173514; NM_001173515; NM_003332; NM_198125
	n/a
	NP_001166985; NP_001166986; NP_003323; NP_937758
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TYROBP yw TYROBP a elwir hefyd yn TYRO protein tyrosine kinase binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TYROBP.

DAP12
KARAP
PLOSL

Llyfryddiaeth

"DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells. ". J Leukoc Biol. 2013. PMID 23715743.
"The association of polar residues in the DAP12 homodimer: TOXCAT and molecular dynamics simulation studies. ". Biophys J. 2013. PMID 23561520.
"TYROBP genetic variants in early-onset Alzheimer's disease. ". Neurobiol Aging. 2016. PMID 27658901.
"Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors. ". Cancer Immunol Res. 2015. PMID 25941351.
"Breast cancer expression of DAP12 is associated with skeletal and liver metastases and poor survival.". Clin Breast Cancer. 2013. PMID 23810293.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TYROBP - Cronfa NCBI

[1]

[2]